Anti-Infective Agents - Volume 10, Issue 1, 2012

s The emergence of new bacterial strains with multiple resistances may lead to the emergence of new hospitalacquired infections that result in high mortality. Research on new antiinfectives must therefore be continued and all possible strategies should be explored. Screening of plant extracts as well as secondary metabolites, aiming to highlight the presence of new compounds with antimicrobial activity is a potential s Read More

Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.

As skin is an integumentary organ of the body, it acts as the portal of entry for extraneous substances for their effective topical and transdermal delivery. Possessing various advantages, it has the limitation of low permeability of drugs across it, limiting the efficacy of drugs. Therefore, various carrier systems have been developed to enhance the permeation to the deep tissues. Most recently, ethosomes have been developed a Read More

The development of antimicrobial agents to treat infections has been one of the most notable medical achievements of the past century. Despite the growing list of azoles, their clinical value has been limited by their relatively high risk of toxicity and the emergence of drug resistance. This necessitates the development of more effective broad spectrum antimicrobials with fewer side effects. We previously described the desi Read More

Recurrent HCV is universal after liver transplantation in patients viremic at the time of transplantation and leads to cirrhosis in up to 30% of patients by five years. Once cirrhosis develops, the risk of hepatic decompensation is 42% per year. This has led to recurrent HCV emerging as an important yet controversial indication for liver retransplantation and a renewed interest in the role of anti-viral therapies. Despite encouraging res Read More

Flavonoids comprise a group of naturally occurring compounds that are known by their biological properties. Antiviral, antibacterial, antifungal, and antimycobacterial activities were analyzed. The results were discussed in terms of the bioactivity tested, and the structure-activity relationship (SAR), bidimensional (2D)- and three-dimensional (3D)- quantitative structure-activity relationship (QSAR) studies carried out on flavones Read More

In silico methods have been used to identify five different classes of compounds as inhibitors of the essential Plasmodium falciparum enzyme lactate dehydrogenase (LDH). The molecules were assayed for in vitro antimalarial activity in both cell- and enzyme-based inhibition models. 5-Bromo-2-hydroxypyridine-3-carboxylic acid 19 is the most active with IC50 of 3.5 nM for chloroquine sensitive and 5 nM for resistant stra Read More

In the present study, some novel Schiff's bases of 4-methyl-2-thiazolamine were synthesized by condensation of 2-amino-4-methylthiazole with different substituted aromatic aldehydes. Structures of newer Schiff's bases were established on the basis of IR, 1HNMR, Mass spectral data and elemental analyses. All the synthesized compounds were obtained in good yields and high purity. The antimicrobial activity of the synthe Read More