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image of Doramectin Induces Apoptosis in B16 Melanoma Cells

Abstract

Introduction/Objective

Metastatic melanoma resists current pharmacological regimens that act through apoptosis. This indicates that therapies acting non-apoptotic cell-death pathways could be pursued. Doramectin has shown promising results in another cancer of neural crest origin, neuroblastoma, through the inhibition of growth autophagy. Our research hypothesis is that doramectin induces autophagy in B16F10 melanoma cells.

Methods

Cells were treated with doramectin (15 uM) or a combination of both doramectin and a cell-death inhibitor, compared to untreated control cells (media), and then analyzed with MTT analysis. Likewise, MDC analysis was completed to detect autophagy involvement with doramectin treatment. Flow cytometry and TUNEL Assay were conducted to observe cell death-related effects.

Results

MTT analysis of doramectin-treated cells displayed a decrease in cell growth compared to control. Apoptotic morphology was prominent in melanoma cells treated with doramectin. Increased autophagy was not detected by fluorometric microscopic analysis. Flow cytometry analysis of doramectin-treated cells showed apoptosis as a major mode of cell death with some necrosis.

Conclusion

Doramectin induces a novel cell-death mechanism in melanoma compared to other forms of cancer and should be studied as an effective anti-cancer agent for melanoma treatment.

© 2024 Bentham Science Publishers
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2024-10-17
2024-12-04

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References

  1. Losina E. Walensky R.P. Geller A. Beddingfield F.C. III Wolf L.L. Gilchrest B.A. Freedberg K.A. Visual screening for malignant melanoma: a cost-effectiveness analysis. Arch. Dermatol. 2007 143 1 21 28 10.1001/archderm.143.1.21 17224538
    [Google Scholar]
  2. D’Arcangelo D. Giampietri C. Muscio M. Scatozza F. Facchiano F. Facchiano A. WIPI1, BAG1, and PEX3 Autophagy‐Related Genes Are Relevant Melanoma Markers. Oxid. Med. Cell. Longev. 2018 2018 1 1471682 10.1155/2018/1471682 30622661
    [Google Scholar]
  3. Kim J.H. Choi H.S. Kim S.L. Lee D.S. The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription and Human Breast Cancer Stem Cell Formation. Cancers (Basel) 2019 11 10 1527 10.3390/cancers11101527 31658701
    [Google Scholar]
  4. Helmbach H. Rossmann E. Kern M.A. Schadendorf D. Drug-resistance in human melanoma. Int. J. Cancer 2001 93 5 617 622 10.1002/ijc.1378 11477569
    [Google Scholar]
  5. Inamdar G.S. Madhunapantula S.V. Robertson G.P. Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail. Biochem. Pharmacol. 2010 80 5 624 637 10.1016/j.bcp.2010.04.029 20450891
    [Google Scholar]
  6. Broussard L. Howland A. Ryu S. Song K. Norris D. Armstrong C.A. Song P.I. Melanoma Cell Death Mechanisms. Chonnam Med. J. 2018 54 3 135 142 10.4068/cmj.2018.54.3.135 30288368
    [Google Scholar]
  7. Mandalà M. Rutkowski P. Rational combination of cancer immunotherapy in melanoma. Virchows Arch. 2019 474 4 433 447 10.1007/s00428‑018‑2506‑y 30552520
    [Google Scholar]
  8. Lee E.F. Harris T.J. Tran S. Evangelista M. Arulananda S. John T. Ramnac C. Hobbs C. Zhu H. Gunasingh G. Segal D. Behren A. Cebon J. Dobrovic A. Mariadason J.M. Strasser A. Rohrbeck L. Haass N.K. Herold M.J. Fairlie W.D. BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival. Cell Death Dis. 2019 10 5 342 10.1038/s41419‑019‑1568‑3 31019203
    [Google Scholar]
  9. Sui Y. Yao H. Li S. Jin L. Shi P. Li Z. Wang G. Lin S. Wu Y. Li Y. Huang L. Liu Q. Lin X. Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway. J. Mol. Med. (Berl.) 2017 95 3 311 322 10.1007/s00109‑016‑1487‑z 27838742
    [Google Scholar]
  10. Denton D. Kumar S. Autophagy-dependent cell death. Cell Death Differ. 2019 26 4 605 616 10.1038/s41418‑018‑0252‑y 30568239
    [Google Scholar]
  11. Kong W. Zhu H. Zheng S. Yin G. Yu P. Shan Y. Liu X. Ying R. Zhu H. Ma S. Larotrectinib induces autophagic cell death through AMPK/mTOR signalling in colon cancer. J. Cell. Mol. Med. 2022 26 21 5539 5550 10.1111/jcmm.17530 36251949
    [Google Scholar]
  12. Tang M. Hu X. Wang Y. Yao X. Zhang W. Yu C. Cheng F. Li J. Fang Q. Ivermectin, a potential anticancer drug derived from an antiparasitic drug. Pharmacol. Res. 2021 163 105207 10.1016/j.phrs.2020.105207 32971268
    [Google Scholar]
  13. Du S. Liang H. Zhou L. Chen C. Sun R. Zhang J. Meng X. Gao A. Effect of doramectin on programmed cell death pathway in glioma cells. Clin. Transl. Oncol. 2023 25 10 2871 2883 10.1007/s12094‑023‑03147‑z 37084153
    [Google Scholar]
  14. Song D. Liang H. Qu B. Li Y. Liu J. Zhang Y. Li L. Hu L. Zhang X. Gao A. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo. J. Cell. Biochem. 2019 120 1 622 633 10.1002/jcb.27420 30596403
    [Google Scholar]
  15. Kaur B. Blavo C. Parmar M.S. Ivermectin: A multifaceted drug with a potential beyond anti-parasitic therapy. Cureus. 2024 16 3 e56025 10.7759/cureus.56025
    [Google Scholar]
  16. Zhang H. Xu X. Xu R. Ye T. Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis. Front. Oncol. 2022 12 989167 https://www.frontiersin.org/articles/10.3389/fonc.2022.989167 10.3389/fonc.2022.989167 36132145
    [Google Scholar]
  17. Wang J.B. Pan H.X. Tang G.L. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg. Med. Chem. Lett. 2011 21 11 3320 3323 10.1016/j.bmcl.2011.04.008 21514826
    [Google Scholar]
  18. Chen C. Liang H. Qin R. Li X. Wang L. Du S. Chen Z. Meng X. Lv Z. Wang Q. Meng J. Gao A. Doramectin inhibits glioblastoma cell survival via regulation of autophagy in vitro and in vivo. Int. J. Oncol. 2022 60 3 29 10.3892/ijo.2022.5319 35137919
    [Google Scholar]
  19. Dou Q. Chen H.N. Wang K. Yuan K. Lei Y. Li K. Lan J. Chen Y. Huang Z. Xie N. Zhang L. Xiang R. Nice E.C. Wei Y. Huang C. Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer. Cancer Res. 2016 76 15 4457 4469 10.1158/0008‑5472.CAN‑15‑2887 27302166
    [Google Scholar]
  20. Byun S. Lee E. Lee K.W. Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int. J. Mol. Sci. 2017 18 9 1959 10.3390/ijms18091959 28895911
    [Google Scholar]
  21. Mainz L. Rosenfeldt M.T. Autophagy and cancer – insights from mouse models. FEBS J. 2018 285 5 792 808 10.1111/febs.14274 28921866
    [Google Scholar]
  22. Klionsky D.J. Abdel-Aziz A.K. Abdelfatah S. Abdellatif M. Abdoli A. Abel S. Abeliovich H. Abildgaard M.H. Abudu Y.P. Acevedo-Arozena A. Adamopoulos I.E. Adeli K. Adolph T.E. Adornetto A. Aflaki E. Agam G. Agarwal A. Aggarwal B.B. Agnello M. Agostinis P. Agrewala J.N. Agrotis A. Aguilar P.V. Ahmad S.T. Ahmed Z.M. Ahumada-Castro U. Aits S. Aizawa S. Akkoc Y. Akoumianaki T. Akpinar H.A. Al-Abd A.M. Al-Akra L. Al-Gharaibeh A. Alaoui-Jamali M.A. Alberti S. Alcocer-Gómez E. Alessandri C. Ali M. Alim Al-Bari M.A. Aliwaini S. Alizadeh J. Almacellas E. Almasan A. Alonso A. Alonso G.D. Altan-Bonnet N. Altieri D.C. Álvarez É.M.C. Alves S. Alves da Costa C. Alzaharna M.M. Amadio M. Amantini C. Amaral C. Ambrosio S. Amer A.O. Ammanathan V. An Z. Andersen S.U. Andrabi S.A. Andrade-Silva M. Andres A.M. Angelini S. Ann D. Anozie U.C. Ansari M.Y. Antas P. Antebi A. Antón Z. Anwar T. Apetoh L. Apostolova N. Araki T. Araki Y. Arasaki K. Araújo W.L. Araya J. Arden C. Arévalo M.A. Arguelles S. Arias E. Arikkath J. Arimoto H. Ariosa A.R. Armstrong-James D. Arnauné-Pelloquin L. Aroca A. Arroyo D.S. Arsov I. Artero R. Asaro D.M.L. Aschner M. Ashrafizadeh M. Ashur-Fabian O. Atanasov A.G. Au A.K. Auberger P. Auner H.W. Aurelian L. Autelli R. Avagliano L. Ávalos Y. Aveic S. Aveleira C.A. Avin-Wittenberg T. Aydin Y. Ayton S. Ayyadevara S. Azzopardi M. Baba M. Backer J.M. Backues S.K. Bae D.H. Bae O.N. Bae S.H. Baehrecke E.H. Baek A. Baek S.H. Baek S.H. Bagetta G. Bagniewska-Zadworna A. Bai H. Bai J. Bai X. Bai Y. Bairagi N. Baksi S. Balbi T. Baldari C.T. Balduini W. Ballabio A. Ballester M. Balazadeh S. Balzan R. Bandopadhyay R. Banerjee S. Banerjee S. Bánréti Á. Bao Y. Baptista M.S. Baracca A. Barbati C. Bargiela A. Barilà D. Barlow P.G. Barmada S.J. Barreiro E. Barreto G.E. Bartek J. Bartel B. Bartolome A. Barve G.R. Basagoudanavar S.H. Bassham D.C. Bast R.C. Jr Basu A. Batoko H. Batten I. Baulieu E.E. Baumgarner B.L. Bayry J. Beale R. Beau I. Beaumatin F. Bechara L.R.G. Beck G.R. Jr Beers M.F. Begun J. Behrends C. Behrens G.M.N. Bei R. Bejarano E. Bel S. Behl C. Belaid A. Belgareh-Touzé N. Bellarosa C. Belleudi F. Belló Pérez M. Bello-Morales R. Beltran J.S.O. Beltran S. Benbrook D.M. Bendorius M. Benitez B.A. Benito-Cuesta I. Bensalem J. Berchtold M.W. Berezowska S. Bergamaschi D. Bergami M. Bergmann A. Berliocchi L. Berlioz-Torrent C. Bernard A. Berthoux L. Besirli C.G. Besteiro S. Betin V.M. Beyaert R. Bezbradica J.S. Bhaskar K. Bhatia-Kissova I. Bhattacharya R. Bhattacharya S. Bhattacharyya S. Bhuiyan M.S. Bhutia S.K. Bi L. Bi X. Biden T.J. Bijian K. Billes V.A. Binart N. Bincoletto C. Birgisdottir A.B. Bjorkoy G. Blanco G. Blas-Garcia A. Blasiak J. Blomgran R. Blomgren K. Blum J.S. Boada-Romero E. Boban M. Boesze-Battaglia K. Boeuf P. Boland B. Bomont P. Bonaldo P. Bonam S.R. Bonfili L. Bonifacino J.S. Boone B.A. Bootman M.D. Bordi M. Borner C. Bornhauser B.C. Borthakur G. Bosch J. Bose S. Botana L.M. Botas J. Boulanger C.M. Boulton M.E. Bourdenx M. Bourgeois B. Bourke N.M. Bousquet G. Boya P. Bozhkov P.V. Bozi L.H.M. Bozkurt T.O. Brackney D.E. Brandts C.H. Braun R.J. Braus G.H. Bravo-Sagua R. Bravo-San Pedro J.M. Brest P. Bringer M.A. Briones-Herrera A. Broaddus V.C. Brodersen P. Brodsky J.L. Brody S.L. Bronson P.G. Bronstein J.M. Brown C.N. Brown R.E. Brum P.C. Brumell J.H. Brunetti-Pierri N. Bruno D. Bryson-Richardson R.J. Bucci C. Buchrieser C. Bueno M. Buitrago-Molina L.E. Buraschi S. Buch S. Buchan J.R. Buckingham E.M. Budak H. Budini M. Bultynck G. Burada F. Burgoyne J.R. Burón M.I. Bustos V. Büttner S. Butturini E. Byrd A. Cabas I. Cabrera-Benitez S. Cadwell K. Cai J. Cai L. Cai Q. Cairó M. Calbet J.A. Caldwell G.A. Caldwell K.A. Call J.A. Calvani R. Calvo A.C. Calvo-Rubio Barrera M. Camara N.O. Camonis J.H. Camougrand N. Campanella M. Campbell E.M. Campbell-Valois F.X. Campello S. Campesi I. Campos J.C. Camuzard O. Cancino J. Candido de Almeida D. Canesi L. Caniggia I. Canonico B. Cantí C. Cao B. Caraglia M. Caramés B. Carchman E.H. Cardenal-Muñoz E. Cardenas C. Cardenas L. Cardoso S.M. Carew J.S. Carle G.F. Carleton G. Carloni S. Carmona-Gutierrez D. Carneiro L.A. Carnevali O. Carosi J.M. Carra S. Carrier A. Carrier L. Carroll B. Carter A.B. Carvalho A.N. Casanova M. Casas C. Casas J. Cassioli C. Castillo E.F. Castillo K. Castillo-Lluva S. Castoldi F. Castori M. Castro A.F. Castro-Caldas M. Castro-Hernandez J. Castro-Obregon S. Catz S.D. Cavadas C. Cavaliere F. Cavallini G. Cavinato M. Cayuela M.L. Cebollada Rica P. Cecarini V. Cecconi F. Cechowska-Pasko M. Cenci S. Ceperuelo-Mallafré V. Cerqueira J.J. Cerutti J.M. Cervia D. Cetintas V.B. Cetrullo S. Chae H.J. Chagin A.S. Chai C.Y. Chakrabarti G. Chakrabarti O. Chakraborty T. Chakraborty T. Chami M. Chamilos G. Chan D.W. Chan E.Y.W. Chan E.D. Chan H.Y.E. Chan H.H. Chan H. Chan M.T.V. Chan Y.S. Chandra P.K. Chang C.P. Chang C. Chang H.C. Chang K. Chao J. Chapman T. Charlet-Berguerand N. Chatterjee S. Chaube S.K. Chaudhary A. Chauhan S. Chaum E. Checler F. Cheetham M.E. Chen C.S. Chen G.C. Chen J.F. Chen L.L. Chen L. Chen L. Chen M. Chen M.K. Chen N. Chen Q. Chen R.H. Chen S. Chen W. Chen W. Chen X.M. Chen X.W. Chen X. Chen Y. Chen Y.G. Chen Y. Chen Y. Chen Y.J. Chen Y.Q. Chen Z.S. Chen Z. Chen Z.H. Chen Z.J. Chen Z. Cheng H. Cheng J. Cheng S.Y. Cheng W. Cheng X. Cheng X.T. Cheng Y. Cheng Z. Chen Z. Cheong H. Cheong J.K. Chernyak B.V. Cherry S. Cheung C.F.R. Cheung C.H.A. Cheung K.H. Chevet E. Chi R.J. Chiang A.K.S. Chiaradonna F. Chiarelli R. Chiariello M. Chica N. Chiocca S. Chiong M. Chiou S.H. Chiramel A.I. Chiurchiù V. Cho D.H. Choe S.K. Choi A.M.K. Choi M.E. Choudhury K.R. Chow N.S. Chu C.T. Chua J.P. Chua J.J.E. Chung H. Chung K.P. Chung S. Chung S.H. Chung Y.L. Cianfanelli V. Ciechomska I.A. Cifuentes M. Cinque L. Cirak S. Cirone M. Clague M.J. Clarke R. Clementi E. Coccia E.M. Codogno P. Cohen E. Cohen M.M. Colasanti T. Colasuonno F. Colbert R.A. Colell A. Čolić M. Coll N.S. Collins M.O. Colombo M.I. Colón-Ramos D.A. Combaret L. Comincini S. Cominetti M.R. Consiglio A. Conte A. Conti F. Contu V.R. Cookson M.R. Coombs K.M. Coppens I. Corasaniti M.T. Corkery D.P. Cordes N. Cortese K. Costa M.D.C. Costantino S. Costelli P. Coto-Montes A. Crack P.J. Crespo J.L. Criollo A. Crippa V. Cristofani R. Csizmadia T. Cuadrado A. Cui B. Cui J. Cui Y. Cui Y. Culetto E. Cumino A.C. Cybulsky A.V. Czaja M.J. Czuczwar S.J. D’Adamo S. D’Amelio M. D’Arcangelo D. D’Lugos A.C. D’Orazi G. da Silva J.A. Dafsari H.S. Dagda R.K. Dagdas Y. Daglia M. Dai X. Dai Y. Dai Y. Dal Col J. Dalhaimer P. Dalla Valle L. Dallenga T. Dalmasso G. Damme M. Dando I. Dantuma N.P. Darling A.L. Das H. Dasarathy S. Dasari S.K. Dash S. Daumke O. Dauphinee A.N. Davies J.S. Dávila V.A. Davis R.J. Davis T. Dayalan Naidu S. De Amicis F. De Bosscher K. De Felice F. De Franceschi L. De Leonibus C. de Mattos Barbosa M.G. De Meyer G.R.Y. De Milito A. De Nunzio C. De Palma C. De Santi M. De Virgilio C. De Zio D. Debnath J. DeBosch B.J. Decuypere J.P. Deehan M.A. Deflorian G. DeGregori J. Dehay B. Del Rio G. Delaney J.R. Delbridge L.M.D. Delorme-Axford E. Delpino M.V. Demarchi F. Dembitz V. Demers N.D. Deng H. Deng Z. Dengjel J. Dent P. Denton D. DePamphilis M.L. Der C.J. Deretic V. Descoteaux A. Devis L. Devkota S. Devuyst O. Dewson G. Dharmasivam M. Dhiman R. di Bernardo D. Di Cristina M. Di Domenico F. Di Fazio P. Di Fonzo A. Di Guardo G. Di Guglielmo G.M. Di Leo L. Di Malta C. Di Nardo A. Di Rienzo M. Di Sano F. Diallinas G. Diao J. Diaz-Araya G. Díaz-Laviada I. Dickinson J.M. Diederich M. Dieudé M. Dikic I. Ding S. Ding W.X. Dini L. Dinić J. Dinic M. Dinkova-Kostova A.T. Dionne M.S. Distler J.H.W. Diwan A. Dixon I.M.C. Djavaheri-Mergny M. Dobrinski I. Dobrovinskaya O. Dobrowolski R. Dobson R.C.J. Đokić J. Dokmeci Emre S. Donadelli M. Dong B. Dong X. Dong Z. Dorn Ii G.W. Dotsch V. Dou H. Dou J. Dowaidar M. Dridi S. Drucker L. Du A. Du C. Du G. Du H.N. Du L.L. du Toit A. Duan S.B. Duan X. Duarte S.P. Dubrovska A. Dunlop E.A. Dupont N. Durán R.V. Dwarakanath B.S. Dyshlovoy S.A. Ebrahimi-Fakhari D. Eckhart L. Edelstein C.L. Efferth T. Eftekharpour E. Eichinger L. Eid N. Eisenberg T. Eissa N.T. Eissa S. Ejarque M. El Andaloussi A. El-Hage N. El-Naggar S. Eleuteri A.M. El-Shafey E.S. Elgendy M. Eliopoulos A.G. Elizalde M.M. Elks P.M. Elsasser H.P. Elsherbiny E.S. Emerling B.M. Emre N.C.T. Eng C.H. Engedal N. Engelbrecht A.M. Engelsen A.S.T. Enserink J.M. Escalante R. Esclatine A. Escobar-Henriques M. Eskelinen E.L. Espert L. Eusebio M.O. Fabrias G. Fabrizi C. Facchiano A. Facchiano F. Fadeel B. Fader C. Faesen A.C. Fairlie W.D. Falcó A. Falkenburger B.H. Fan D. Fan J. Fan Y. Fang E.F. Fang Y. Fang Y. Fanto M. Farfel-Becker T. Faure M. Fazeli G. Fedele A.O. Feldman A.M. Feng D. Feng J. Feng L. Feng Y. Feng Y. Feng W. Fenz Araujo T. Ferguson T.A. Fernández Á.F. Fernandez-Checa J.C. Fernández-Veledo S. Fernie A.R. Ferrante A.W. Jr Ferraresi A. Ferrari M.F. Ferreira J.C.B. Ferro-Novick S. Figueras A. Filadi R. Filigheddu N. Filippi-Chiela E. Filomeni G. Fimia G.M. Fineschi V. Finetti F. Finkbeiner S. Fisher E.A. Fisher P.B. Flamigni F. Fliesler S.J. Flo T.H. Florance I. Florey O. Florio T. Fodor E. Follo C. Fon E.A. Forlino A. Fornai F. Fortini P. Fracassi A. Fraldi A. Franco B. Franco R. Franconi F. Frankel L.B. Friedman S.L. Fröhlich L.F. Frühbeck G. Fuentes J.M. Fujiki Y. Fujita N. Fujiwara Y. Fukuda M. Fulda S. Furic L. Furuya N. Fusco C. Gack M.U. Gaffke L. Galadari S. Galasso A. Galindo M.F. Gallolu Kankanamalage S. Galluzzi L. Galy V. Gammoh N. Gan B. Ganley I.G. Gao F. Gao H. Gao M. Gao P. Gao S.J. Gao W. Gao X. Garcera A. Garcia M.N. Garcia V.E. García-Del Portillo F. Garcia-Escudero V. Garcia-Garcia A. Garcia-Macia M. García-Moreno D. Garcia-Ruiz C. García-Sanz P. Garg A.D. Gargini R. Garofalo T. Garry R.F. Gassen N.C. Gatica D. Ge L. Ge W. Geiss-Friedlander R. Gelfi C. Genschik P. Gentle I.E. Gerbino V. Gerhardt C. Germain K. Germain M. Gewirtz D.A. Ghasemipour Afshar E. Ghavami S. Ghigo A. Ghosh M. Giamas G. Giampietri C. Giatromanolaki A. Gibson G.E. Gibson S.B. Ginet V. Giniger E. Giorgi C. Girao H. Girardin S.E. Giridharan M. Giuliano S. Giulivi C. Giuriato S. Giustiniani J. Gluschko A. Goder V. Goginashvili A. Golab J. Goldstone D.C. Golebiewska A. Gomes L.R. Gomez R. Gómez-Sánchez R. Gomez-Puerto M.C. Gomez-Sintes R. Gong Q. Goni F.M. González-Gallego J. Gonzalez-Hernandez T. Gonzalez-Polo R.A. Gonzalez-Reyes J.A. González-Rodríguez P. Goping I.S. Gorbatyuk M.S. Gorbunov N.V. Görgülü K. Gorojod R.M. Gorski S.M. Goruppi S. Gotor C. Gottlieb R.A. Gozes I. Gozuacik D. Graef M. Gräler M.H. Granatiero V. Grasso D. Gray J.P. Green D.R. Greenhough A. Gregory S.L. Griffin E.F. Grinstaff M.W. Gros F. Grose C. Gross A.S. Gruber F. Grumati P. Grune T. Gu X. Guan J.L. Guardia C.M. Guda K. Guerra F. Guerri C. Guha P. Guillén C. Gujar S. Gukovskaya A. Gukovsky I. Gunst J. Günther A. Guntur A.R. Guo C. Guo C. Guo H. Guo L.W. Guo M. Gupta P. Gupta S.K. Gupta S. Gupta V.B. Gupta V. Gustafsson A.B. Gutterman D.D. H B R. Haapasalo A. Haber J.E. Hać A. Hadano S. Hafrén A.J. Haidar M. Hall B.S. Halldén G. Hamacher-Brady A. Hamann A. Hamasaki M. Han W. Hansen M. Hanson P.I. Hao Z. Harada M. Harhaji-Trajkovic L. Hariharan N. Haroon N. Harris J. Hasegawa T. Hasima Nagoor N. Haspel J.A. Haucke V. Hawkins W.D. Hay B.A. Haynes C.M. Hayrabedyan S.B. Hays T.S. He C. He Q. He R.R. He Y.W. He Y.Y. Heakal Y. Heberle A.M. Hejtmancik J.F. Helgason G.V. Henkel V. Herb M. Hergovich A. Herman-Antosiewicz A. Hernández A. Hernandez C. Hernandez-Diaz S. Hernandez-Gea V. Herpin A. Herreros J. Hervás J.H. Hesselson D. Hetz C. Heussler V.T. Higuchi Y. Hilfiker S. Hill J.A. Hlavacek W.S. Ho E.A. Ho I.H.T. Ho P.W. Ho S.L. Ho W.Y. Hobbs G.A. Hochstrasser M. Hoet P.H.M. Hofius D. Hofman P. Höhn A. Holmberg C.I. Hombrebueno J.R. Yi-Ren Hong C.H. Hooper L.V. Hoppe T. Horos R. Hoshida Y. Hsin I.L. Hsu H.Y. Hu B. Hu D. Hu L.F. Hu M.C. Hu R. Hu W. Hu Y.C. Hu Z.W. Hua F. Hua J. Hua Y. Huan C. Huang C. Huang C. Huang C. Huang C. Huang H. Huang K. Huang M.L.H. Huang R. Huang S. Huang T. Huang X. Huang Y.J. Huber T.B. Hubert V. Hubner C.A. Hughes S.M. Hughes W.E. Humbert M. Hummer G. Hurley J.H. Hussain S. Hussain S. Hussey P.J. Hutabarat M. Hwang H.Y. Hwang S. Ieni A. Ikeda F. Imagawa Y. Imai Y. Imbriano C. Imoto M. Inman D.M. Inoki K. Iovanna J. Iozzo R.V. Ippolito G. Irazoqui J.E. Iribarren P. Ishaq M. Ishikawa M. Ishimwe N. Isidoro C. Ismail N. Issazadeh-Navikas S. Itakura E. Ito D. Ivankovic D. Ivanova S. Iyer A.K.V. Izquierdo J.M. Izumi M. Jäättelä M. Jabir M.S. Jackson W.T. Jacobo-Herrera N. Jacomin A.C. Jacquin E. Jadiya P. Jaeschke H. Jagannath C. Jakobi A.J. Jakobsson J. Janji B. Jansen-Dürr P. Jansson P.J. Jantsch J. Januszewski S. Jassey A. Jean S. Jeltsch-David H. Jendelova P. Jenny A. Jensen T.E. Jessen N. Jewell J.L. Ji J. Jia L. Jia R. Jiang L. Jiang Q. Jiang R. Jiang T. Jiang X. Jiang Y. Jimenez-Sanchez M. Jin E.J. Jin F. Jin H. Jin L. Jin L. Jin M. Jin S. Jo E.K. Joffre C. Johansen T. Johnson G.V.W. Johnston S.A. Jokitalo E. Jolly M.K. Joosten L.A.B. Jordan J. Joseph B. Ju D. Ju J.S. Ju J. Juárez E. Judith D. Juhász G. Jun Y. Jung C.H. Jung S.C. Jung Y.K. Jungbluth H. Jungverdorben J. Just S. Kaarniranta K. Kaasik A. Kabuta T. Kaganovich D. Kahana A. Kain R. Kajimura S. Kalamvoki M. Kalia M. Kalinowski D.S. Kaludercic N. Kalvari I. Kaminska J. Kaminskyy V.O. Kanamori H. Kanasaki K. Kang C. Kang R. Kang S.S. Kaniyappan S. Kanki T. Kanneganti T.D. Kanthasamy A.G. Kanthasamy A. Kantorow M. Kapuy O. Karamouzis M.V. Karim M.R. Karmakar P. Katare R.G. Kato M. Kaufmann S.H.E. Kauppinen A. Kaushal G.P. Kaushik S. Kawasaki K. Kazan K. Ke P.Y. Keating D.J. Keber U. Kehrl J.H. Keller K.E. Keller C.W. Kemper J.K. Kenific C.M. Kepp O. Kermorgant S. Kern A. Ketteler R. Keulers T.G. Khalfin B. Khalil H. Khambu B. Khan S.Y. Khandelwal V.K.M. Khandia R. Kho W. Khobrekar N.V. Khuansuwan S. Khundadze M. Killackey S.A. Kim D. Kim D.R. Kim D.H. Kim D.E. Kim E.Y. Kim E.K. Kim H.R. Kim H.S. Hyung-Ryong Kim Kim J.H. Kim J.K. Kim J.H. Kim J. Kim J.H. Kim K.I. Kim P.K. Kim S.J. Kimball S.R. Kimchi A. Kimmelman A.C. Kimura T. King M.A. Kinghorn K.J. Kinsey C.G. Kirkin V. Kirshenbaum L.A. Kiselev S.L. Kishi S. Kitamoto K. Kitaoka Y. Kitazato K. Kitsis R.N. Kittler J.T. Kjaerulff O. Klein P.S. Klopstock T. Klucken J. Knævelsrud H. Knorr R.L. Ko B.C.B. Ko F. Ko J.L. Kobayashi H. Kobayashi S. Koch I. Koch J.C. Koenig U. Kögel D. Koh Y.H. Koike M. Kohlwein S.D. Kocaturk N.M. Komatsu M. König J. Kono T. Kopp B.T. Korcsmaros T. Korkmaz G. Korolchuk V.I. Korsnes M.S. Koskela A. Kota J. Kotake Y. Kotler M.L. Kou Y. Koukourakis M.I. Koustas E. Kovacs A.L. Kovács T. Koya D. Kozako T. Kraft C. Krainc D. Krämer H. Krasnodembskaya A.D. Kretz-Remy C. Kroemer G. Ktistakis N.T. Kuchitsu K. Kuenen S. Kuerschner L. Kukar T. Kumar A. Kumar A. Kumar D. Kumar D. Kumar S. Kume S. Kumsta C. Kundu C.N. Kundu M. Kunnumakkara A.B. Kurgan L. Kutateladze T.G. Kutlu O. Kwak S. Kwon H.J. Kwon T.K. Kwon Y.T. Kyrmizi I. La Spada A. Labonté P. Ladoire S. Laface I. Lafont F. Lagace D.C. Lahiri V. Lai Z. Laird A.S. Lakkaraju A. Lamark T. Lan S.H. Landajuela A. Lane D.J.R. Lane J.D. Lang C.H. Lange C. Langel Ü. Langer R. Lapaquette P. Laporte J. LaRusso N.F. Lastres-Becker I. Lau W.C.Y. Laurie G.W. Lavandero S. Law B.Y.K. Law H.K. Layfield R. Le W. Le Stunff H. Leary A.Y. Lebrun J.J. Leck L.Y.W. Leduc-Gaudet J.P. Lee C. Lee C.P. Lee D.H. Lee E.B. Lee E.F. Lee G.M. Lee H.J. Lee H.K. Lee J.M. Lee J.S. Lee J.A. Lee J.Y. Lee J.H. Lee M. Lee M.G. Lee M.J. Lee M.S. Lee S.Y. Lee S.J. Lee S.Y. Lee S.B. Lee W.H. Lee Y.R. Lee Y.H. Lee Y. Lefebvre C. Legouis R. Lei Y.L. Lei Y. Leikin S. Leitinger G. Lemus L. Leng S. Lenoir O. Lenz G. Lenz H.J. Lenzi P. León Y. Leopoldino A.M. Leschczyk C. Leskelä S. Letellier E. Leung C.T. Leung P.S. Leventhal J.S. Levine B. Lewis P.A. Ley K. Li B. Li D.Q. Li J. Li J. Li J. Li K. Li L. Li M. Li M. Li M. Li M. Li M. Li P.L. Li M.Q. Li Q. Li S. Li T. Li W. Li W. Li X. Li Y.P. Li Y. Li Z. Li Z. Li Z. Lian J. Liang C. Liang Q. Liang W. Liang Y. Liang Y. Liao G. Liao L. Liao M. Liao Y.F. Librizzi M. Lie P.P.Y. Lilly M.A. Lim H.J. Lima T.R.R. Limana F. Lin C. Lin C.W. Lin D.S. Lin F.C. Lin J.D. Lin K.M. Lin K.H. Lin L.T. Lin P.H. Lin Q. Lin S. Lin S.J. Lin W. Lin X. Lin Y.X. Lin Y.S. Linden R. Lindner P. Ling S.C. Lingor P. Linnemann A.K. Liou Y.C. Lipinski M.M. Lipovšek S. Lira V.A. Lisiak N. Liton P.B. Liu C. Liu C.H. Liu C.F. Liu C.H. Liu F. Liu H. Liu H.S. Liu H.F. Liu H. Liu J. Liu J. Liu J. Liu L. Liu L. Liu M. Liu Q. Liu W. Liu W. Liu X.H. Liu X. Liu X. Liu X. Liu X. Liu Y. Liu Y. Liu Y. Liu Y. Liu Y. Livingston J.A. Lizard G. Lizcano J.M. Ljubojevic-Holzer S. LLeonart M.E. Llobet-Navàs D. Llorente A. Lo C.H. Lobato-Márquez D. Long Q. Long Y.C. Loos B. Loos J.A. López M.G. López-Doménech G. López-Guerrero J.A. López-Jiménez A.T. López-Pérez Ó. López-Valero I. Lorenowicz M.J. Lorente M. Lorincz P. Lossi L. Lotersztajn S. Lovat P.E. Lovell J.F. Lovy A. Lőw P. Lu G. Lu H. Lu J.H. Lu J.J. Lu M. Lu S. Luciani A. Lucocq J.M. Ludovico P. Luftig M.A. Luhr M. Luis-Ravelo D. Lum J.J. Luna-Dulcey L. Lund A.H. Lund V.K. Lünemann J.D. Lüningschrör P. Luo H. Luo R. Luo S. Luo Z. Luparello C. Lüscher B. Luu L. Lyakhovich A. Lyamzaev K.G. Lystad A.H. Lytvynchuk L. Ma A.C. Ma C. Ma M. Ma N.F. Ma Q.H. Ma X. Ma Y. Ma Z. MacDougald O.A. Macian F. MacIntosh G.C. MacKeigan J.P. Macleod K.F. Maday S. Madeo F. Madesh M. Madl T. Madrigal-Matute J. Maeda A. Maejima Y. Magarinos M. Mahavadi P. Maiani E. Maiese K. Maiti P. Maiuri M.C. Majello B. Major M.B. Makareeva E. Malik F. Mallilankaraman K. Malorni W. Maloyan A. Mammadova N. Man G.C.W. Manai F. Mancias J.D. Mandelkow E.M. Mandell M.A. Manfredi A.A. Manjili M.H. Manjithaya R. Manque P. Manshian B.B. Manzano R. Manzoni C. Mao K. Marchese C. Marchetti S. Marconi A.M. Marcucci F. Mardente S. Mareninova O.A. Margeta M. Mari M. Marinelli S. Marinelli O. Mariño G. Mariotto S. Marshall R.S. Marten M.R. Martens S. Martin A.P.J. Martin K.R. Martin S. Martin S. Martín-Segura A. Martín-Acebes M.A. Martin-Burriel I. Martin-Rincon M. Martin-Sanz P. Martina J.A. Martinet W. Martinez A. Martinez A. Martinez J. Martinez Velazquez M. Martinez-Lopez N. Martinez-Vicente M. Martins D.O. Martins J.O. Martins W.K. Martins-Marques T. Marzetti E. Masaldan S. Masclaux-Daubresse C. Mashek D.G. Massa V. Massieu L. Masson G.R. Masuelli L. Masyuk A.I. Masyuk T.V. Matarrese P. Matheu A. Matoba S. Matsuzaki S. Mattar P. Matte A. Mattoscio D. Mauriz J.L. Mauthe M. Mauvezin C. Maverakis E. Maycotte P. Mayer J. Mazzoccoli G. Mazzoni C. Mazzulli J.R. McCarty N. McDonald C. McGill M.R. McKenna S.L. McLaughlin B. McLoughlin F. McNiven M.A. McWilliams T.G. Mechta-Grigoriou F. Medeiros T.C. Medina D.L. Megeney L.A. Megyeri K. Mehrpour M. Mehta J.L. Meijer A.J. Meijer A.H. Mejlvang J. Meléndez A. Melk A. Memisoglu G. Mendes A.F. Meng D. Meng F. Meng T. Menna-Barreto R. Menon M.B. Mercer C. Mercier A.E. Mergny J.L. Merighi A. Merkley S.D. Merla G. Meske V. Mestre A.C. Metur S.P. Meyer C. Meyer H. Mi W. Mialet-Perez J. Miao J. Micale L. Miki Y. Milan E. Milczarek M. Miller D.L. Miller S.I. Miller S. Millward S.W. Milosevic I. Minina E.A. Mirzaei H. Mirzaei H.R. Mirzaei M. Mishra A. Mishra N. Mishra P.K. Misirkic Marjanovic M. Misasi R. Misra A. Misso G. Mitchell C. Mitou G. Miura T. Miyamoto S. Miyazaki M. Miyazaki M. Miyazaki T. Miyazawa K. Mizushima N. Mogensen T.H. Mograbi B. Mohammadinejad R. Mohamud Y. Mohanty A. Mohapatra S. Möhlmann T. Mohmmed A. Moles A. Moley K.H. Molinari M. Mollace V. Møller A.B. Mollereau B. Mollinedo F. Montagna C. Monteiro M.J. Montella A. Montes L.R. Montico B. Mony V.K. Monzio Compagnoni G. Moore M.N. Moosavi M.A. Mora A.L. Mora M. Morales-Alamo D. Moratalla R. Moreira P.I. Morelli E. Moreno S. Moreno-Blas D. Moresi V. Morga B. Morgan A.H. Morin F. Morishita H. Moritz O.L. Moriyama M. Moriyasu Y. Morleo M. Morselli E. Moruno-Manchon J.F. Moscat J. Mostowy S. Motori E. Moura A.F. Moustaid-Moussa N. Mrakovcic M. Muciño-Hernández G. Mukherjee A. Mukhopadhyay S. Mulcahy Levy J.M. Mulero V. Muller S. Münch C. Munjal A. Munoz-Canoves P. Muñoz-Galdeano T. Münz C. Murakawa T. Muratori C. Murphy B.M. Murphy J.P. Murthy A. Myöhänen T.T. Mysorekar I.U. Mytych J. Nabavi S.M. Nabissi M. Nagy P. Nah J. Nahimana A. Nakagawa I. Nakamura K. Nakatogawa H. Nandi S.S. Nanjundan M. Nanni M. Napolitano G. Nardacci R. Narita M. Nassif M. Nathan I. Natsumeda M. Naude R.J. Naumann C. Naveiras O. Navid F. Nawrocki S.T. Nazarko T.Y. Nazio F. Negoita F. Neill T. Neisch A.L. Neri L.M. Netea M.G. Neubert P. Neufeld T.P. Neumann D. Neutzner A. Newton P.T. Ney P.A. Nezis I.P. Ng C.C.W. Ng T.B. Nguyen H.T.T. Nguyen L.T. Ni H.M. Ní Cheallaigh C. Ni Z. Nicolao M.C. Nicoli F. Nieto-Diaz M. Nilsson P. Ning S. Niranjan R. Nishimune H. Niso-Santano M. Nixon R.A. Nobili A. Nobrega C. Noda T. Nogueira-Recalde U. Nolan T.M. Nombela I. Novak I. Novoa B. Nozawa T. Nukina N. Nussbaum-Krammer C. Nylandsted J. O’Donovan T.R. O’Leary S.M. O’Rourke E.J. O’Sullivan M.P. O’Sullivan T.E. Oddo S. Oehme I. Ogawa M. Ogier-Denis E. Ogmundsdottir M.H. Ogretmen B. Oh G.T. Oh S.H. Oh Y.J. Ohama T. Ohashi Y. Ohmuraya M. Oikonomou V. Ojha R. Okamoto K. Okazawa H. Oku M. Oliván S. Oliveira J.M.A. Ollmann M. Olzmann J.A. Omari S. Omary M.B. Önal G. Ondrej M. Ong S.B. Ong S.G. Onnis A. Orellana J.A. Orellana-Muñoz S. Ortega-Villaizan M.D.M. Ortiz-Gonzalez X.R. Ortona E. Osiewacz H.D. Osman A.K. Osta R. Otegui M.S. Otsu K. Ott C. Ottobrini L. Ou J.J. Outeiro T.F. Oynebraten I. Ozturk M. Pagès G. Pahari S. Pajares M. Pajvani U.B. Pal R. Paladino S. Pallet N. Palmieri M. Palmisano G. Palumbo C. Pampaloni F. Pan L. Pan Q. Pan W. Pan X. Panasyuk G. Pandey R. Pandey U.B. Pandya V. Paneni F. Pang S.Y. Panzarini E. Papademetrio D.L. Papaleo E. Papinski D. Papp D. Park E.C. Park H.T. Park J.M. Park J.I. Park J.T. Park J. Park S.C. Park S.Y. Parola A.H. Parys J.B. Pasquier A. Pasquier B. Passos J.F. Pastore N. Patel H.H. Patschan D. Pattingre S. Pedraza-Alva G. Pedraza-Chaverri J. Pedrozo Z. Pei G. Pei J. Peled-Zehavi H. Pellegrini J.M. Pelletier J. Peñalva M.A. Peng D. Peng Y. Penna F. Pennuto M. Pentimalli F. Pereira C.M. Pereira G.J.S. Pereira L.C. Pereira de Almeida L. Perera N.D. Pérez-Lara Á. Perez-Oliva A.B. Pérez-Pérez M.E. Periyasamy P. Perl A. Perrotta C. Perrotta I. Pestell R.G. Petersen M. Petrache I. Petrovski G. Pfirrmann T. Pfister A.S. Philips J.A. Pi H. Picca A. Pickrell A.M. Picot S. Pierantoni G.M. Pierdominici M. Pierre P. Pierrefite-Carle V. Pierzynowska K. Pietrocola F. Pietruczuk M. Pignata C. Pimentel-Muiños F.X. Pinar M. Pinheiro R.O. Pinkas-Kramarski R. Pinton P. Pircs K. Piya S. Pizzo P. Plantinga T.S. Platta H.W. Plaza-Zabala A. Plomann M. Plotnikov E.Y. Plun-Favreau H. Pluta R. Pocock R. Pöggeler S. Pohl C. Poirot M. Poletti A. Ponpuak M. Popelka H. Popova B. Porta H. Porte Alcon S. Portilla-Fernandez E. Post M. Potts M.B. Poulton J. Powers T. Prahlad V. Prajsnar T.K. Praticò D. Prencipe R. Priault M. Proikas-Cezanne T. Promponas V.J. Proud C.G. Puertollano R. Puglielli L. Pulinilkunnil T. Puri D. Puri R. Puyal J. Qi X. Qi Y. Qian W. Qiang L. Qiu Y. Quadrilatero J. Quarleri J. Raben N. Rabinowich H. Ragona D. Ragusa M.J. Rahimi N. Rahmati M. Raia V. Raimundo N. Rajasekaran N.S. Ramachandra Rao S. Rami A. Ramírez-Pardo I. Ramsden D.B. Randow F. Rangarajan P.N. Ranieri D. Rao H. Rao L. Rao R. Rathore S. Ratnayaka J.A. Ratovitski E.A. Ravanan P. Ravegnini G. Ray S.K. Razani B. Rebecca V. Reggiori F. Régnier-Vigouroux A. Reichert A.S. Reigada D. Reiling J.H. Rein T. Reipert S. Rekha R.S. Ren H. Ren J. Ren W. Renault T. Renga G. Reue K. Rewitz K. Ribeiro de Andrade Ramos B. Riazuddin S.A. Ribeiro-Rodrigues T.M. Ricci J.E. Ricci R. Riccio V. Richardson D.R. Rikihisa Y. Risbud M.V. Risueño R.M. Ritis K. Rizza S. Rizzuto R. Roberts H.C. Roberts L.D. Robinson K.J. Roccheri M.C. Rocchi S. Rodney G.G. Rodrigues T. Rodrigues Silva V.R. Rodriguez A. Rodriguez-Barrueco R. Rodriguez-Henche N. Rodriguez-Rocha H. Roelofs J. Rogers R.S. Rogov V.V. Rojo A.I. Rolka K. Romanello V. Romani L. Romano A. Romano P.S. Romeo-Guitart D. Romero L.C. Romero M. Roney J.C. Rongo C. Roperto S. Rosenfeldt M.T. Rosenstiel P. Rosenwald A.G. Roth K.A. Roth L. Roth S. Rouschop K.M.A. Roussel B.D. Roux S. Rovere-Querini P. Roy A. Rozieres A. Ruano D. Rubinsztein D.C. Rubtsova M.P. Ruckdeschel K. Ruckenstuhl C. Rudolf E. Rudolf R. Ruggieri A. Ruparelia A.A. Rusmini P. Russell R.R. Russo G.L. Russo M. Russo R. Ryabaya O.O. Ryan K.M. Ryu K.Y. Sabater-Arcis M. Sachdev U. Sacher M. Sachse C. Sadhu A. Sadoshima J. Safren N. Saftig P. Sagona A.P. Sahay G. Sahebkar A. Sahin M. Sahin O. Sahni S. Saito N. Saito S. Saito T. Sakai R. Sakai Y. Sakamaki J.I. Saksela K. Salazar G. Salazar-Degracia A. Salekdeh G.H. Saluja A.K. Sampaio-Marques B. Sanchez M.C. Sanchez-Alcazar J.A. Sanchez-Vera V. Sancho-Shimizu V. Sanderson J.T. Sandri M. Santaguida S. Santambrogio L. Santana M.M. Santoni G. Sanz A. Sanz P. Saran S. Sardiello M. Sargeant T.J. Sarin A. Sarkar C. Sarkar S. Sarrias M.R. Sarkar S. Sarmah D.T. Sarparanta J. Sathyanarayan A. Sathyanarayanan R. Scaglione K.M. Scatozza F. Schaefer L. Schafer Z.T. Schaible U.E. Schapira A.H.V. Scharl M. Schatzl H.M. Schein C.H. Scheper W. Scheuring D. Schiaffino M.V. Schiappacassi M. Schindl R. Schlattner U. Schmidt O. Schmitt R. Schmidt S.D. Schmitz I. Schmukler E. Schneider A. Schneider B.E. Schober R. Schoijet A.C. Schott M.B. Schramm M. Schröder B. Schuh K. Schüller C. Schulze R.J. Schürmanns L. Schwamborn J.C. Schwarten M. Scialo F. Sciarretta S. Scott M.J. Scotto K.W. Scovassi A.I. Scrima A. Scrivo A. Sebastian D. Sebti S. Sedej S. Segatori L. Segev N. Seglen P.O. Seiliez I. Seki E. Selleck S.B. Sellke F.W. Selsby J.T. Sendtner M. Senturk S. Seranova E. Sergi C. Serra-Moreno R. Sesaki H. Settembre C. Setty S.R.G. Sgarbi G. Sha O. Shacka J.J. Shah J.A. Shang D. Shao C. Shao F. Sharbati S. Sharkey L.M. Sharma D. Sharma G. Sharma K. Sharma P. Sharma S. Shen H.M. Shen H. Shen J. Shen M. Shen W. Shen Z. Sheng R. Sheng Z. Sheng Z.H. Shi J. Shi X. Shi Y.H. Shiba-Fukushima K. Shieh J.J. Shimada Y. Shimizu S. Shimozawa M. Shintani T. Shoemaker C.J. Shojaei S. Shoji I. Shravage B.V. Shridhar V. Shu C.W. Shu H.B. Shui K. Shukla A.K. Shutt T.E. Sica V. Siddiqui A. Sierra A. Sierra-Torre V. Signorelli S. Sil P. Silva B.J.A. Silva J.D. Silva-Pavez E. Silvente-Poirot S. Simmonds R.E. Simon A.K. Simon H.U. Simons M. Singh A. Singh L.P. Singh R. Singh S.V. Singh S.K. Singh S.B. Singh S. Singh S.P. Sinha D. Sinha R.A. Sinha S. Sirko A. Sirohi K. Sivridis E.L. Skendros P. Skirycz A. Slaninová I. Smaili S.S. Smertenko A. Smith M.D. Soenen S.J. Sohn E.J. Sok S.P.M. Solaini G. Soldati T. Soleimanpour S.A. Soler R.M. Solovchenko A. Somarelli J.A. Sonawane A. Song F. Song H.K. Song J.X. Song K. Song Z. Soria L.R. Sorice M. Soukas A.A. Soukup S.F. Sousa D. Sousa N. Spagnuolo P.A. Spector S.A. Srinivas Bharath M.M. St Clair D. Stagni V. Staiano L. Stalnecker C.A. Stankov M.V. Stathopulos P.B. Stefan K. Stefan S.M. Stefanis L. Steffan J.S. Steinkasserer A. Stenmark H. Sterneckert J. Stevens C. Stoka V. Storch S. Stork B. Strappazzon F. Strohecker A.M. Stupack D.G. Su H. Su L.Y. Su L. Suarez-Fontes A.M. Subauste C.S. Subbian S. Subirada P.V. Sudhandiran G. Sue C.M. Sui X. Summers C. Sun G. Sun J. Sun K. Sun M.X. Sun Q. Sun Y. Sun Z. Sunahara K.K.S. Sundberg E. Susztak K. Sutovsky P. Suzuki H. Sweeney G. Symons J.D. Sze S.C.W. Szewczyk N.J. Tabęcka-Łonczynska A. Tabolacci C. Tacke F. Taegtmeyer H. Tafani M. Tagaya M. Tai H. Tait S.W.G. Takahashi Y. Takats S. Talwar P. Tam C. Tam S.Y. Tampellini D. Tamura A. Tan C.T. Tan E.K. Tan Y.Q. Tanaka M. Tanaka M. Tang D. Tang J. Tang T.S. Tanida I. Tao Z. Taouis M. Tatenhorst L. Tavernarakis N. Taylor A. Taylor G.A. Taylor J.M. Tchetina E. Tee A.R. Tegeder I. Teis D. Teixeira N. Teixeira-Clerc F. Tekirdag K.A. Tencomnao T. Tenreiro S. Tepikin A.V. Testillano P.S. Tettamanti G. Tharaux P.L. Thedieck K. Thekkinghat A.A. Thellung S. Thinwa J.W. Thirumalaikumar V.P. Thomas S.M. Thomes P.G. Thorburn A. Thukral L. Thum T. Thumm M. Tian L. Tichy A. Till A. Timmerman V. Titorenko V.I. Todi S.V. Todorova K. Toivonen J.M. Tomaipitinca L. Tomar D. Tomas-Zapico C. Tomić S. Tong B.C. Tong C. Tong X. Tooze S.A. Torgersen M.L. Torii S. Torres-López L. Torriglia A. Towers C.G. Towns R. Toyokuni S. Trajkovic V. Tramontano D. Tran Q.G. Travassos L.H. Trelford C.B. Tremel S. Trougakos I.P. Tsao B.P. Tschan M.P. Tse H.F. Tse T.F. Tsugawa H. Tsvetkov A.S. Tumbarello D.A. Tumtas Y. Tuñón M.J. Turcotte S. Turk B. Turk V. Turner B.J. Tuxworth R.I. Tyler J.K. Tyutereva E.V. Uchiyama Y. Ugun-Klusek A. Uhlig H.H. Ułamek-Kozioł M. Ulasov I.V. Umekawa M. Ungermann C. Unno R. Urbe S. Uribe-Carretero E. Üstün S. Uversky V.N. Vaccari T. Vaccaro M.I. Vahsen B.F. Vakifahmetoglu-Norberg H. Valdor R. Valente M.J. Valko A. Vallee R.B. Valverde A.M. Van den Berghe G. van der Veen S. Van Kaer L. van Loosdregt J. van Wijk S.J.L. Vandenberghe W. Vanhorebeek I. Vannier-Santos M.A. Vannini N. Vanrell M.C. Vantaggiato C. Varano G. Varela-Nieto I. Varga M. Vasconcelos M.H. Vats S. Vavvas D.G. Vega-Naredo I. Vega-Rubin-de-Celis S. Velasco G. Velázquez A.P. Vellai T. Vellenga E. Velotti F. Verdier M. Verginis P. Vergne I. Verkade P. Verma M. Verstreken P. Vervliet T. Vervoorts J. Vessoni A.T. Victor V.M. Vidal M. Vidoni C. Vieira O.V. Vierstra R.D. Viganó S. Vihinen H. Vijayan V. Vila M. Vilar M. Villalba J.M. Villalobo A. Villarejo-Zori B. Villarroya F. Villarroya J. Vincent O. Vindis C. Viret C. Viscomi M.T. Visnjic D. Vitale I. Vocadlo D.J. Voitsekhovskaja O.V. Volonté C. Volta M. Vomero M. Von Haefen C. Vooijs M.A. Voos W. Vucicevic L. Wade-Martins R. Waguri S. Waite K.A. Wakatsuki S. Walker D.W. Walker M.J. Walker S.A. Walter J. Wandosell F.G. Wang B. Wang C.Y. Wang C. Wang C. Wang C. Wang C.Y. Wang D. Wang F. Wang F. Wang F. Wang G. Wang H. Wang H. Wang H. Wang H.G. Wang J. Wang J. Wang J. Wang J. Wang K. Wang L. Wang L. Wang M.H. Wang M. Wang N. Wang P. Wang P. Wang P. Wang P. Wang Q.J. Wang Q. Wang Q.K. Wang Q.A. Wang W.T. Wang W. Wang X. Wang X. Wang Y. Wang Y. Wang Y. Wang Y.Y. Wang Y. Wang Y. Wang Y. Wang Y. Wang Z. Wang Z. Wang Z. Warnes G. Warnsmann V. Watada H. Watanabe E. Watchon M. Wawrzyńska A. Weaver T.E. Wegrzyn G. Wehman A.M. Wei H. Wei L. Wei T. Wei Y. Weiergräber O.H. Weihl C.C. Weindl G. Weiskirchen R. Wells A. Wen R.H. Wen X. Werner A. Weykopf B. Wheatley S.P. Whitton J.L. Whitworth A.J. Wiktorska K. Wildenberg M.E. Wileman T. Wilkinson S. Willbold D. Williams B. Williams R.S.B. Williams R.L. Williamson P.R. Wilson R.A. Winner B. Winsor N.J. Witkin S.S. Wodrich H. Woehlbier U. Wollert T. Wong E. Wong J.H. Wong R.W. Wong V.K.W. Wong W.W. Wu A.G. Wu C. Wu J. Wu J. Wu K.K. Wu M. Wu S.Y. Wu S. Wu S.Y. Wu S. Wu W.K.K. Wu X. Wu X. Wu Y.W. Wu Y. Xavier R.J. Xia H. Xia L. Xia Z. Xiang G. Xiang J. Xiang M. Xiang W. Xiao B. Xiao G. Xiao H. Xiao H.T. Xiao J. Xiao L. Xiao S. Xiao Y. Xie B. Xie C.M. Xie M. Xie Y. Xie Z. Xie Z. Xilouri M. Xu C. Xu E. Xu H. Xu J. Xu J. Xu L. Xu W.W. Xu X. Xue Y. Yakhine-Diop S.M.S. Yamaguchi M. Yamaguchi O. Yamamoto A. Yamashina S. Yan S. Yan S.J. Yan Z. Yanagi Y. Yang C. Yang D.S. Yang H. Yang H.T. Yang H. Yang J.M. Yang J. Yang J. Yang L. Yang L. Yang M. Yang P.M. Yang Q. Yang S. Yang S. Yang S.F. Yang W. Yang W.Y. Yang X. Yang X. Yang Y. Yang Y. Yao H. Yao S. Yao X. Yao Y.G. Yao Y.M. Yasui T. Yazdankhah M. Yen P.M. Yi C. Yin X.M. Yin Y. Yin Z. Yin Z. Ying M. Ying Z. Yip C.K. Yiu S.P.T. Yoo Y.H. Yoshida K. Yoshii S.R. Yoshimori T. Yousefi B. Yu B. Yu H. Yu J. Yu J. Yu L. Yu M.L. Yu S.W. Yu V.C. Yu W.H. Yu Z. Yu Z. Yuan J. Yuan L.Q. Yuan S. Yuan S.F. Yuan Y. Yuan Z. Yue J. Yue Z. Yun J. Yung R.L. Zacks D.N. Zaffagnini G. Zambelli V.O. Zanella I. Zang Q.S. Zanivan S. Zappavigna S. Zaragoza P. Zarbalis K.S. Zarebkohan A. Zarrouk A. Zeitlin S.O. Zeng J. Zeng J.D. Žerovnik E. Zhan L. Zhang B. Zhang D.D. Zhang H. Zhang H. Zhang H. Zhang H. Zhang H. Zhang H. Zhang H. Zhang H.L. Zhang J. Zhang J. Zhang J.P. Zhang K.Y.B. Zhang L.W. Zhang L. Zhang L. Zhang L. Zhang L. Zhang M. Zhang P. Zhang S. Zhang W. Zhang X. Zhang X.W. Zhang X. Zhang X. Zhang X. Zhang X. Zhang X.D. Zhang Y. Zhang Y. Zhang Y. Zhang Y.D. Zhang Y. Zhang Y.Y. Zhang Y. Zhang Z. Zhang Z. Zhang Z. Zhang Z. Zhang Z. Zhang Z. Zhao H. Zhao L. Zhao S. Zhao T. Zhao X.F. Zhao Y. Zhao Y. Zhao Y. Zhao Y. Zheng G. Zheng K. Zheng L. Zheng S. Zheng X.L. Zheng Y. Zheng Z.G. Zhivotovsky B. Zhong Q. Zhou A. Zhou B. Zhou C. Zhou G. Zhou H. Zhou H. Zhou H. Zhou J. Zhou J. Zhou J. Zhou J. Zhou K. Zhou R. Zhou X.J. Zhou Y. Zhou Y. Zhou Y. Zhou Z.Y. Zhou Z. Zhu B. Zhu C. Zhu G.Q. Zhu H. Zhu H. Zhu H. Zhu W.G. Zhu Y. Zhu Y. Zhuang H. Zhuang X. Zientara-Rytter K. Zimmermann C.M. Ziviani E. Zoladek T. Zong W.X. Zorov D.B. Zorzano A. Zou W. Zou Z. Zou Z. Zuryn S. Zwerschke W. Brand-Saberi B. Dong X.C. Kenchappa C.S. Li Z. Lin Y. Oshima S. Rong Y. Sluimer J.C. Stallings C.L. Tong C.K. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021 17 1 1 382 10.1080/15548627.2020.1797280 33634751
    [Google Scholar]
  23. Ndoye A. Weeraratna A.T. Autophagy- An emerging target for melanoma therapy. F1000Res 2016 5 F1000
    [Google Scholar]
  24. Sumithra U. B16-F10: a murine melanoma model. 2019 Available from: https://www.labcorp.com/b16-f10-murine-melanoma-model(accessed on 30-8-2024)
  25. Glinsky G.V. Glinsky V.V. Apoptosis and metastasis: a superior resistance of metastatic cancer cells to programmed cell death. Cancer Lett. 1996 101 1 43 51 10.1016/0304‑3835(96)04112‑2 8625281
    [Google Scholar]
  26. Mustika R. Budiyanto A. Nishigori C. Ichihashi M. Ueda M. Decreased expression of Apaf‐1 with progression of melanoma. Pigment Cell Res. 2005 18 1 59 62 10.1111/j.1600‑0749.2004.00205.x 15649154
    [Google Scholar]
  27. Chu H. Li M. Wang X. Capsaicin induces apoptosis and autophagy in human melanoma cells. Oncol. Lett. 2019 17 6 4827 4834 10.3892/ol.2019.10206 31186689
    [Google Scholar]
  28. Jeon S.J. Choi E.Y. Han E.J. Lee S.W. Moon J.M. Jung S.H. Jung J.Y. Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells. Int. J. Mol. Med. 2023 52 6 115 10.3892/ijmm.2023.5318 37830157
    [Google Scholar]
  29. Kosic M. Paunovic V. Ristic B. Mircic A. Bosnjak M. Stevanovic D. Kravic-Stevovic T. Trajkovic V. Harhaji-Trajkovic L. 3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms. J. Pharmacol. Sci. 2021 147 1 156 167 10.1016/j.jphs.2021.06.003 34294367
    [Google Scholar]
  30. McAfee Q. Zhang Z. Samanta A. Levi S.M. Ma X.H. Piao S. Lynch J.P. Uehara T. Sepulveda A.R. Davis L.E. Winkler J.D. Amaravadi R.K. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc. Natl. Acad. Sci. USA 2012 109 21 8253 8258 10.1073/pnas.1118193109 22566612
    [Google Scholar]
  31. Ahmad H. Crotts M.S. Jacobs J.C. Baer R.W. Cox J.L. Shikonin Causes Non-apoptotic Cell Death in B16F10 Melanoma. Anticancer Agents Med Chem. 2023 23 16 1880 1887 10.2174/1871520623666230701000338
    [Google Scholar]
  32. Van P. Jiang W. Gottardo R. Finak G. ggCyto: next generation open-source visualization software for cytometry. Bioinformatics 2018 34 22 3951 3953 10.1093/bioinformatics/bty441 29868771
    [Google Scholar]
  33. Hammill D. DillonHammill/CytoExploreR. 2021 Available from:https://github.com/DillonHammill/CytoExploreR(accessed on 30-8-2024)
  34. Finak G. Jiang M. flowWorkspace: Infrastructure for representing and interacting with gated and ungated cytometry data sets.. R package version 4.16.0. 2024 Available from:https://bioconductor.org/packages/flowWorkspace(accessed on 30-8-2024)
  35. Finak G. Frelinger J. Jiang W. Newell E.W. Ramey J. Davis M.M. Kalams S.A. De Rosa S.C. Gottardo R. OpenCyto: an open source infrastructure for scalable, robust, reproducible, and automated, end-to-end flow cytometry data analysis. PLOS Comput. Biol. 2014 10 8 e1003806 10.1371/journal.pcbi.1003806 25167361
    [Google Scholar]
  36. Murugan S. Amaravadi R.K. Methods for Studying Autophagy Within the Tumor Microenvironment. Adv. Exp. Med. Biol. 2016 899 145 166 10.1007/978‑3‑319‑26666‑4_9 27325266
    [Google Scholar]
  37. The R project for statistical computing. 2024 Available from:https://www.R-project.org/(accessed on 30-8-2024)
  38. Wickham H. Averick M. Bryan J. Chang W. McGowan L. François R. Grolemund G. Hayes A. Henry L. Hester J. Kuhn M. Pedersen T. Miller E. Bache S. Müller K. Ooms J. Robinson D. Seidel D. Spinu V. Takahashi K. Vaughan D. Wilke C. Woo K. Yutani H. Welcome to the Tidyverse. J. Open Source Softw. 2019 4 43 1686 10.21105/joss.01686
    [Google Scholar]
  39. Fox J. Weisberg S. An R Companion to Applied Regression. 2019 Available from: https://socialsciences.mcmaster.ca/jfox/Books/Companion/(accessed on 30-8-2024)
  40. Kassambara A. rstatix: Pipe-Friendly Framework for Basic Statistical Tests. 2023 Available from: https://CRAN.R-project.org/package=rstatix(accessed on 30-8-2024)
  41. Siddiqui S. Deshmukh A.J. Mudaliar P. Nalawade A.J. Iyer D. Aich J. Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review. J. Egypt. Natl. Canc. Inst. 2022 34 1 33 10.1186/s43046‑022‑00137‑0 35934727
    [Google Scholar]
  42. Martin R.J. Robertson A.P. Choudhary S. Ivermectin: An Anthelmintic, an Insecticide, and Much More. Trends Parasitol. 2021 37 1 48 64 10.1016/j.pt.2020.10.005 33189582
    [Google Scholar]
  43. Li N. Zhan X. Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes. EPMA J. 2020 11 2 289 309 10.1007/s13167‑020‑00209‑y 32549918
    [Google Scholar]
  44. Luo H. Feng Y. Wang F. Lin Z. Huang J. Li Q. Wang X. Liu X. Zhai X. Gao Q. Li L. Zhang Y. Wen J. Zhang L. Niu T. Zheng Y. Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma. Cancer Lett. 2023 565 216218 10.1016/j.canlet.2023.216218 37149018
    [Google Scholar]
  45. Dueñas-González A. Juárez-Rodríguez M. Ivermectin: Potential Repurposing of a Versatile Antiparasitic as a Novel Anticancer. Drug Repurposing - Molecular Aspects and Therapeutic Applications IntechOpen 2022
    [Google Scholar]
  46. Song D. Liang H. Qu B. Li Y. Liu J. Zhang Y. Li L. Hu L. Zhang X. Gao A. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo. J. Cell. Biochem. 2019 120 1 622 633 10.1002/jcb.27420 30596403
    [Google Scholar]
  47. Laing R. Gillan V. Devaney E. Ivermectin – Old Drug, New Tricks? Trends Parasitol. 2017 33 6 463 472 10.1016/j.pt.2017.02.004 28285851
    [Google Scholar]
  48. Crump A. Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations. J. Antibiot. (Tokyo) 2017 70 5 495 505 10.1038/ja.2017.11 28196978
    [Google Scholar]
  49. Zhou S. Wu H. Ning W. Wu X. Xu X. Ma Y. Li X. Hu J. Wang C. Wang J. Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth. Front. Pharmacol. 2021 12 717529 10.3389/fphar.2021.717529 34483925
    [Google Scholar]
  50. Lee D.E. Kang H.W. Kim S.Y. Kim M.J. Jeong J.W. Hong W.C. Fang S. Kim H.S. Lee Y.S. Kim H.J. Park J.S. Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction. Front. Pharmacol. 2022 13 934746 10.3389/fphar.2022.934746 36091811
    [Google Scholar]
  51. Zhang X. Qin T. Zhu Z. Hong F. Xu Y. Zhang X. Xu X. Ma A. Ivermectin Augments the In Vitro and In Vivo Efficacy of Cisplatin in Epithelial Ovarian Cancer by Suppressing Akt/mTOR Signaling. Am. J. Med. Sci. 2020 359 2 123 129 10.1016/j.amjms.2019.11.001 32039764
    [Google Scholar]
  52. Gao A. Wang X. Xiang W. Liang H. Gao J. Yan Y. Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. J. Pharm. Pharmacol. 2010 62 3 393 399 10.1211/jpp.62.03.0016 20487225
    [Google Scholar]
  53. Liu J. Liang H. Chen C. Wang X. Qu F. Wang H. Yang K. Wang Q. Zhao N. Meng J. Gao A. Ivermectin induces autophagy-mediated cell death through the AKT/mTOR signaling pathway in glioma cells. Biosci. Rep. 2019 39 12 BSR20192489 10.1042/BSR20192489 31755894
    [Google Scholar]
  54. Cavalcante G.C. Schaan A.P. Cabral G.F. Santana-da-Silva M.N. Pinto P. Vidal A.F. Ribeiro-dos-Santos Â. A Cell’s Fate: An Overview of the Molecular Biology and Genetics of Apoptosis. Int. J. Mol. Sci. 2019 20 17 4133 10.3390/ijms20174133 31450613
    [Google Scholar]
  55. Enari M. Sakahira H. Yokoyama H. Okawa K. Iwamatsu A. Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998 391 6662 43 50 10.1038/34112 9422506
    [Google Scholar]
  56. Gao W. Wang X. Zhou Y. Wang X. Yu Y. Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct. Target. Ther. 2022 7 1 196 10.1038/s41392‑022‑01046‑3 35725836
    [Google Scholar]
  57. Yang H. Ma Y. Chen G. Zhou H. Yamazaki T. Klein C. Pietrocola F. Vacchelli E. Souquere S. Sauvat A. Zitvogel L. Kepp O. Kroemer G. Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy. OncoImmunology 2016 5 6 e1149673 10.1080/2162402X.2016.1149673 27471616
    [Google Scholar]
  58. Wang Y.Y. Shi L.Y. Zhu Z.T. Wang Q.J. A new pyroptosis model can predict the immunotherapy response and immune microenvironment characteristics and prognosis of patients with cutaneous melanoma based on TCGA and GEO databases. Ann. Transl. Med. 2022 10 6 353 353 10.21037/atm‑22‑1095 35434038
    [Google Scholar]
  59. Camilio K.A. Berge G. Ravuri C.S. Rekdal Ø. Sveinbjørnsson B. Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315. Cancer Immunol. Immunother. 2014 63 6 601 613 10.1007/s00262‑014‑1540‑0 24676901
    [Google Scholar]
  60. Del Bello B. Toscano M. Moretti D. Maellaro E. Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells. PLoS One 2013 8 2 e57236 10.1371/journal.pone.0057236 23437349
    [Google Scholar]
  61. Mariño G. Niso-Santano M. Baehrecke E.H. Kroemer G. Self-consumption: the interplay of autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2014 15 2 81 94 10.1038/nrm3735 24401948
    [Google Scholar]
  62. Sun Z. Zheng L. Liu X. Xing W. Liu X. Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition. Drug Des. Devel. Ther. 2018 12 2413 2421 10.2147/DDDT.S155798 30122899
    [Google Scholar]
  63. Ishibashi Y. Nakamura O. Yamagami Y. Nishimura H. Fukuoka N. Yamamoto T. Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells. Anticancer Res. 2019 39 2 649 654 10.21873/anticanres.13159 30711941
    [Google Scholar]
  64. Wang F.T. Wang H. Wang Q.W. Pan M.S. Li X.P. Sun W. Fan Y.Z. Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer. Cancer Chemother. Pharmacol. 2020 86 2 221 232 10.1007/s00280‑020‑04100‑5 32654071
    [Google Scholar]
  65. Petiot A. Ogier-Denis E. Blommaart E.F.C. Meijer A.J. Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 2000 275 2 992 998 10.1074/jbc.275.2.992 10625637
    [Google Scholar]
  66. Ahmad H. Crotts M.S. Jacobs J.C. Baer R.W. Cox J.L. Shikonin Causes Non-apoptotic Cell Death in B16F10 Melanoma. Anticancer. Agents Med. Chem. 2023 23 16 1880 1887 10.2174/1871520623666230701000338 37393553
    [Google Scholar]
  67. Kroemer G. Galluzzi L. Vandenabeele P. Abrams J. Alnemri E.S. Baehrecke E.H. Blagosklonny M.V. El-Deiry W.S. Golstein P. Green D.R. Hengartner M. Knight R.A. Kumar S. Lipton S.A. Malorni W. Nuñez G. Peter M.E. Tschopp J. Yuan J. Piacentini M. Zhivotovsky B. Melino G. Nomenclature Committee on Cell Death 2009 Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2009 16 1 3 11 10.1038/cdd.2008.150 18846107
    [Google Scholar]
  68. Filomeni G. De Zio D. Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2015 22 3 377 388 10.1038/cdd.2014.150 25257172
    [Google Scholar]
  69. Roca-Agujetas V. de Dios C. Lestón L. Marí M. Morales A. Colell A. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxid. Med. Cell. Longev. 2019 2019 1 16 10.1155/2019/3809308 31781334
    [Google Scholar]
  70. Hseu Y.C. Chiang Y.C. Vudhya Gowrisankar Y. Lin K.Y. Huang S.T. Shrestha S. Chang G.R. Yang H.L. The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells. Cancers (Basel) 2020 12 10 2936 10.3390/cancers12102936 33053749
    [Google Scholar]
  71. Jung C.H. Ro S.H. Cao J. Otto N.M. Kim D.H. mTOR regulation of autophagy. FEBS Lett. 2010 584 7 1287 1295 10.1016/j.febslet.2010.01.017 20083114
    [Google Scholar]
  72. Zheng Y. Wang K. Wu Y. Chen Y. Chen X. Hu C.W. Hu F. Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells. Cancer Lett. 2018 431 31 42 10.1016/j.canlet.2018.05.026 29807112
    [Google Scholar]
  73. White E. Autophagy and p53. Cold Spring Harb. Perspect. Med. 2016 6 4 a026120 10.1101/cshperspect.a026120 27037419
    [Google Scholar]
  74. Maiuri M.C. Galluzzi L. Morselli E. Kepp O. Malik S.A. Kroemer G. Autophagy regulation by p53. Curr. Opin. Cell Biol. 2010 22 2 181 185 10.1016/j.ceb.2009.12.001 20044243
    [Google Scholar]
  75. Shim D. P53-regulated autophagy and its impact on drug resistance and cell fate. Cancer Drug Resist. 2021 4 1 85 95
    [Google Scholar]
  76. Xing Y. Wei X. Liu Y. Wang M.M. Sui Z. Wang X. Zhu W. Wu M. Lu C. Fei Y.H. Jiang Y. Zhang Y. Wang Y. Guo F. Cao J.L. Qi J. Wang W. Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. Autophagy 2022 18 8 1932 1954 10.1080/15548627.2021.2008752 34878954
    [Google Scholar]
  77. Zheng X. Zhang J. Li S. Gao X. Zhang Y. Wang M. Dong L. Sun L. Zhao N. Ma Z. Ding C. Wang Y. Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis. Transl. Oncol. 2022 21 101425 10.1016/j.tranon.2022.101425 35460941
    [Google Scholar]
  78. Sui X. Jin L. Huang X. Geng S. He C. Hu X. p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment. Autophagy 2011 7 6 565 571 10.4161/auto.7.6.14073 21099252
    [Google Scholar]
  79. Li M.Y. Zhang J. Lu X. Zhou D. Deng X.F. Liu Q.X. Dai J.G. Zheng H. Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells. Cancer Chemother. Pharmacol. 2024 93 1 41 54 10.1007/s00280‑023‑04589‑6 37741955
    [Google Scholar]
/content/journals/acamc/10.2174/0118715206325844240909144543
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Doramectin Induces Apoptosis in B16 Melanoma Cells
Bentham Science Publishers ; https://doi.org/10.2174/0118715206325844240909144543
/content/journals/acamc/10.2174/0118715206325844240909144543
/content/journals/acamc/10.2174/0118715206325844240909144543
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  • Article Type:     Research Article
Keywords: autophagy ; cell death ; cancer ; ivermectin ; doramectin ; Melanoma ; apoptosis

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