Reviews on Recent Clinical Trials - Volume 17, Issue 3, 2022

Perianal fistulizing Crohn’s disease (PFCD) is a disabling complication of Crohn’s disease (CD) that can significantly impact the patients’ quality of life (QoL) and often requires multidisciplinary care. Clinical trials assessing the efficacy of medical and surgical interventions for fistulas usually evaluate outcomes such as the closure of fistula tracts or radiologic healing. However, these traditional outcome assessments fail to capture the i Read More

Background: Anxiety and depression are the most common psychological disorders found in Inflammatory Bowel Disease (IBD) patients. Accurate measuring of these disorders should be proposed for prompt management. Patient-reported outcome measurements (PROMs) allow patients to self-report their psychological symptoms. Objective: The objective of this study is to highlight the presence of PROMs measuring anxiety Read More

Background: Psoriasis is a chronic relapsing immune-mediated disease leading to a strong impact on patient’s quality of life. The treatment of psoriasis has undergone a revolution with the advent of biological therapies. Currently, Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores are in use to assess the overall severity of pathology. A new self-administered questionnaire, the Psoriasi Read More

Background: Although mood disorders have been well characterized by immunemediated inflammatory diseases, physical function and satisfaction with social roles have not yet been defined as independent domains. Objective: The study aims to assess satisfaction with social roles and physical function alterations in a population with immune-mediated inflammatory diseases and identify associated characteristics. Methods: Phys Read More

Background: Recent literature suggests that the respiratory rate oxygenation (ROX) index may be useful in predicting intubation indication in hypoxemic patients. Objective: In this study, we evaluated the accuracy of the ROX index in predicting intubation, length of stay in the ICU, and mortality in ICU patients with hypoxemic respiratory failure with and without hypercapnia. Methods: A single-centre retrospective cohort Read More

Background: Highly Active Antiretroviral Therapy (HAART) is composed of several drugs in the antiretroviral class to better treat human immunodeficiency virus type 1 (HIV-1) patients. The estimation of CD4+ T cell counts and HIV-1 viral load in plasma is required to evaluate the treatment success of a specific HAART. Methodology: The study included the effects of NRTIs (nucleoside reverse transcriptase inhibitors Read More

Background: Tonsillectomy is one of the most common surgical procedures. This study compared the effect of Pregabalin and Clonidine on postoperative pain in adult patients undergoing elective tonsillectomy. Methods: This randomized, double-blind, prospective clinical trial was conducted among 92 patients aged 20 to 50. The clonidine group (C) was given 150 μg of clonidine tablet 90 minutes before surgery, an Read More

Background: Hepatic encephalopathy is defined as a spectrum of neuropsychiatric disorders in patients with liver dysfunction, usually cirrhosis, after exclusion of brain disease. This study reports the role of manganese in brain alterations and clinical manifestations of hepatic encephalopathy. Case presentation: Male patient, 67 years old, suffering from alcoholic liver cirrhosis and two previous episodes of hepatic encephalopat Read More