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Reviews on Recent Clinical Trials - Online First
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Immune Checkpoint Inhibitors Impact Fertility: A Review
Authors: Iram Shabir and Christina FosterAvailable online: 04 February 2025More LessImmune checkpoint inhibitor therapy has become the established method of treatment for various types of cancers, consequently introducing a spectrum of side effects referred to as immune-mediated adverse events, affecting almost every organ, including the reproductive system. Moreover, very little clinical data is available that suggests the detrimental effect of immune checkpoint inhibitor therapy on fertility, sex Read More
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The Effect of Foot Reflexology on the Sexual Function of Lactating Women: A Randomized Clinical Trial
Authors: Zahra Ghanbari, Mahboubeh Valiani and Shahnaz KohanAvailable online: 04 February 2025More LessBackground Sexual health is an essential part of women's lives at different ages. Pregnancy, childbirth, and breastfeeding can affect women's sexual function by inducing biological, psychological, and social changes. Due to the prevalence of sexual dysfunction in lactating women and the effects of reflexology therapies on it, this study was conducted to investigate the effect of foot reflexology on the sexual function of lact Read More
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From Paper to Digital: Evaluating Electronic Medical Records and their Compliance with EMA Guidelines in European Clinical Trials
Available online: 27 January 2025More LessBackground Over the past decade, there has been a significant shift from paper-based to digital medical record management, driven largely by advances in digital technology. This transition has led to widespread adoption of Electronic Medical Records (EMRs), with the expectation that paper documentation will soon be fully replaced. In response, the European Medicines Agency's “Guideline on Computerised Systems in Clinical Read More
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New Research on Biomarkers in Alzheimer’s Continuum
Authors: Immacolata Vecchio and Carmela ColicaAvailable online: 24 January 2025More LessAlzheimer’s disease (AD) is a multifactorial pathology, responsible for neurodegenerative disorders which in more than 60% of patients evolve into dementia. Comprehension of the molecular mechanisms underlying the pathology and the development of reliable diagnostic methods have made new and more effective therapies possible. In recent years, in addition to the classic anticholinesterases (AChEs), which can control the Read More
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Blockchain as a Prime Guardian: Securing Clinical Trial Data Integrity
Authors: Nikhil Sethi, Charul Rathore and Dilpreet SinghAvailable online: 23 January 2025More LessThe present study focuses on the possible use of the emerging technology of blockchain in ensuring data management security in clinical trials. With the determination of the chief researchers and clinical investigations becoming more and more complex and international, achieving data quality and integrity, transparency, and legal compliance becomes imperative. By offering a distributed and immutable time-stamped le Read More
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Navigating Dry Eye Research: A Comprehensive Review of Etiology, Clinical Trials, Patents, and Recent Advancements
Authors: Vindhya Pal and Sushma VermaAvailable online: 09 October 2024More LessBackground Millions of people worldwide suffer from dry eye disease. Dry eye, a multifunctional condition of the ocular surface, typically occurs in conjunction with an unbalanced tear film. With increasing age, the dry eye problem becomes worse. Aqueous-deficit dry eye and evaporative dry eye are the two traditional classifications for dry eye. Various examination tools are used to diagnose dry eye. Clinical trials are conduct Read More
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COVID-19 Vaccinations: Summary Guidance for Cancer Patients in 28 Languages: Breaking Barriers to Cancer Patient Information
Authors: Davide Mauri, Konstantinos Kamposioras, Lampriani Tsali, Mario Dambrosio, Berardino De Bari, Nadia Hindi, Carl Salembier, Joanna Nixon, Tzachanis Dimitrios, Flippo Alongi, Hassan Hameed, Antonios Valachis, Konstantinos Papadimitriou, Stefanie Corradini, Lazar Popovic, Jindrich Kopecky, Andres Rodriguez, Katarina Antunac, Junlin Yi, Jozsef Lovey, Primoz Strojan, Haytham Saraireh, Ranveig Røtterud, Marzanna Chojnacka, Santa C. Olalla, Natalia Chilingirova, Ramon Andrade De Mello, Giovanna Araujo Amaral, Farsid Arbabi, Radu Vidra, Erjeta Rapushi, Dan Takeuchi, Chirstos Christopoulos, Irina Ivanova, Igor Djan, Branka Petricevic, Francesco Cellini, Iglika Mihaylova, Natalija Dedic Plavetic, Cvetka Grašič Kuhar, Elena Takeuchi, Pantelis Kountourakis, Panagiotis Ntellas, Ioanna Gazouli, Stefania Gkoura, Salih Yuce, Özlem ER, Chait Yasmina, Gireesh Kumaran, Orges Spahiu, Aasim Yusuf, Paulina Gono, Kathi Apostolidis and Maria Tolia
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Deep Neck Infections: Decisional Algorithm for Patients with Multiple Spaces Involvement
Authors: Filippo Ricciardiello, Salvatore Mazzone, Pasquale Viola, Gianluca Guggino, Giuseppe Longo, Alberto Napolitano, Giuseppe Russo, Giulio Sequino, Flavia Oliva, Pasquale Salomone, Marco Perrella, Giovanni M. Romano, Pietro Cinaglia, Teresa Abate, Maurizio Gargiulo, Davide Pisani and Giuseppe Chiarella
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