Reviews on Recent Clinical Trials - Volume 12, Issue 1, 2017

Background: Recursive Partitioning Analysis (RPA) is a very flexible non parametric algorithm that allows classification of individuals according to certain criteria, particularly in clinical trials, the method is used to predict response to treatment or classify individuals according to prognostic factors. Objectives: In this paper we examine how often RPA is used in clinical trials and in meta-analysis. Methods: We reviewed abstrac Read More

Type 2 Diabetes Mellitus (T2DM) is a chronic illness with high prevalence in Mexico, Latin- America, and the world and is associated to high morbidity, disability, and mortality rate, especially in developing countries. T2DM physiopathology is very complex; insulin resistance in the muscle, liver, and adipose tissue, a reduction in the production of incretins (mainly GLP-1) in the intestine, increased glucagon synthesis, an insuf Read More

Background: The Ewing sarcoma (ES) represents 10 to 15% malignant bone tumors and 40 to 45% pediatric malignant bone tumors. The aim of this review is to clarify the therapeutic results and prognostic factors of this entity. Methods: A systematic review of the literature was performed. Studies focused on the management of ES were considered for inclusion. Result: ES represents a model of multidisciplinary approach. T Read More

Background: Physicians encounter various symptom-based complaints each day. While physicians strive to support patients with chronic illnesses, evidence indicates that patients who are actively involved in their health care have better health outcomes and sometimes lowers costs. Aim: This article is to analyze how patient engagement is described when complex interventions such as Tai Chi were delivered in Randomized Co Read More

Background: Dyspepsia is one of the most frequent ailments in the Iranian community. Fuelled by a growing interest in understanding drugs and self-medication for common conditions such as dyspepsia, the public increasingly seeks health advice from professionals such as community pharmacists. The purpose of our study was to assess dyspepsia-related knowledge of pharmacists in Iran. Methods: This cross-sectional Read More

Introduction: There are no reliable non-invasive markers of restenosis after Percutaneous Coronary Interventions (PCIs). The aim of our study was to measure changes incorrected QT interval (QTc), corrected QT dispersion (QTcd), corrected T wave peak to end interval (TPEc) and corrected TPE dispersion (TPEcd) after PCI and to determine whether restenosis subsequently affects these indices. Methods: From 211 patients, who u Read More

Background: HIV-infected patients may be at a greater risk of Hospital-Acquired Infections (HAIs) but risks factors for HAIs have not been well described in this population. Objective: The aim of this study was to examine the incidence, temporal trends and risk factors of HAIs among adult HIV positive patients. Methods: This was a retrospective cohort study carried out in an academic health system in New York City which in Read More

Purpose: There has been a long-standing interest in the investigation of interactions in science. The objective of the study is to evaluate interaction between Epidermal Growth Factor Receptor (EGFR) mutation and treatment from randomized, phase II study of chemotherapy versus chemotherapy plus erlotinib in patients with progressive Non-Small Cell Lung Cancer (NSCLC) following clinical benefit from erlotinib. Ma Read More

Background: Antimicrobial prophylaxis should be used in circumstances where efficacy has been demonstrated and benefits outweigh the risk. Each hospital must have an antibiotic policy that is implementable and fully adhered to. Methods: A prospective observational study was conducted in 209 patients, admitted to wards of various surgical departments including surgery, obstetrics & gynaecology (O), otorhinolaryngology Read More