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- Volume 11, Issue 2, 2016
Reviews on Recent Clinical Trials - Volume 11, Issue 2, 2016
Volume 11, Issue 2, 2016
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Immune Check Point Inhibitors Combination in Melanoma: Worth the Toxicity?
Authors: Marlana Orloff, Ryan Weight, Matias E. Valsecchi and Takami SatoThe combination of immune checkpoint inhibitors ipilimumab and nivolumab has been recently been FDA approved for first line treatment of unresectable and metastatic BRAF wild type melanoma. The approval came following the impressive results of the CheckMate 067, where the combination of ipilimumab and nivolumab appeared to outperform each as a single agent in regards to response rate and progression f Read More
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Immunotherapy for Non-Small Cell Lung Cancer - Finally a Hint of Hope
Lung cancer is a major public health problem worldwide and the leading cause of cancerrelated mortality in developed countries. Significant advances have been made especially with the discovery of targeted agents. However, only a small proportion of patients carry activating mutations; until recently conventional chemotherapy and angiogenesis inhibitors were the preferred treatment for the vast majority of p Read More
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What is the Current Role of Immunotherapy for Colon Cancer?
Colon cancer is a leading cause of cancer related mortality. Until very recently the only existing options that medical oncologists had to treat metastatic colon cancer were a combination of chemotherapy, anti-EGFR and anti-angiogenic agents. We currently have the first proof that immune therapies could be an effective approach to battle colorectal cancers that carry a mismatch repair machinery deficient phenoty Read More
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Overcoming Resistance to EGFR Inhibitors in NSCLC
Background: The clarification of several molecular pathways underlying the tumorigenesis has led to the development of several targeted drugs that have substantially improved the treatment of Non-Small-Cell Lung Cancer (NSCLC). The Epidermal Growth Factor Receptor (EGFR) is the target of several Tyrosine-Kinase Inhibitors (TKIs), some of them approved for treatment and others currently in clinical development. EGFR-TK Read More
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Novel Methods of Insulin Replacement: The Artificial Pancreas and Encapsulated Islets
Authors: Rana Malek and Stephen N. DavisType 1 diabetes represents 5-10% of patients with diabetes worldwide. The importance of tight glycemic control has been demonstrated definitively in the Diabetes Control and Complications Trial but is often elusive for patients because of the associated risk of hypoglycemia. Care for these patients requires coordination amongst a variety of health professionals including primary care providers, endocrinologists, nephrologist Read More
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Maintenance Therapy in Multiple Myeloma: Novel Concepts in Clinical Practice from Recent Clinical Trials
More LessThe introduction of novel drugs in multiple myeloma therapy has changed disease survivals in last 15 years. Besides to be more effective in this disease new agents have been utilized in novel strategies such as consolidation and maintenance therapy. Lenalidomide has been one of the favourite in clinical trials because of its oral administration, and bortezomib has been utilized too after the drug has been proved to be e Read More
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Assessment of Possible Drug Interactions in Patients with Psoriasis and Associated Comorbid Medical Conditions: An Observational Study
Authors: Reena Sherin and Padmaja UdaykumarBackground: Associated co-morbidities with psoriasis are treated with concomitant medications apart from the antipsoriatic therapy and the resulting Drug-Drug Interactions (DDI) may affect therapeutic outcome. Objective: To assess the DDI in psoriatic patients with co-morbidities. Method: In this prospective observational analysis, 150 prescriptions of psoriatic patients, receiving two or more drugs were analysed usi Read More
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To Be-et, or Not to Be-et, That is the Question: The Role(s) of Nitrate and Nitrite in Health and Illness
More LessBackground: This manuscript addresses the multilevel role of dietary nitrate and nitrite in health and diseases because of increased interest in dietary supplementation. Method: Review of research devoted to both beneficial but also possible deleterious effects of uncontrolled indigestion of red beet-root juice and other sources of high concentrated nitrate and nitrite. Results: The body of evidence strongly suggested that per Read More
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The Difficulties in the Management of Breast Cancer and Pregnancy
Authors: Wala B. Kridis, Jihène Feki, Afef Khanfir, Nabile Toumi, Tahia Boudawara, Jamel Daoud and Mounir FrikhaIntroduction: Breast cancer and pregnancy is rare. It is defined by the discovery of breast cancer during pregnancy or within one year after delivery. Throughout this study, we analyzed the characteristics of this entity with review of the literature. Materials and Methods: We report through a retrospective study of breast cancer in pregnant women, a series of 11 cases collected at the oncology department in Sfax be Read More
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HIV Vaccination, is Breakthrough Underway?
Authors: Da-Yong Lu, Hong-Ying Wu, Ting-Ren Lu, Bin Xu and Jian DingAfter long defeats-almost no marked breakthrough in HIV vaccination campaign has been observed during the past two decades, and we still have not lost our faiths for the development of highly effective and low risk HIV vaccines. Many effective vaccines have been discovered and will certainly enter into the markets within the next 5 to 10 years. In order to promote HIV vaccine developments and clinical HIV therapeutic improve Read More
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Non-cirrhotic Portal Hypertension Associated with Didanosine and Streptococcus agalactiae Infection: A Case Report
Authors: Vesna Turkulov, Maja Ruzic, Dajana Lendak, Daniela Maric, Snezana Brkic and Ludovico AbenavoliBackground: Non-Cirrhotic Portal Hypertension (NCPH) is a rare but potentially fatal liver disorder described in patients treated with anti-retroviral therapy for Human Immunodeficiency Virus (HIV). In particular, the most important predisposing factor to its development has been identified as prolonged exposure to Didanosine (ddI). The clinical entity of NCPH is characterized by an increase in portal pressure due to pre- or intr Read More
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Volumes & issues
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Volume 20 (2025)
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Volume 19 (2024)
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Volume 18 (2023)
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Volume 17 (2022)
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Volume 16 (2021)
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Volume 15 (2020)
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Volume 14 (2019)
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Volume 13 (2018)
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Volume 12 (2017)
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Volume 11 (2016)
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Volume 10 (2015)
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Volume 9 (2014)
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Volume 8 (2013)
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Volume 7 (2012)
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Volume 6 (2011)
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Volume 5 (2010)
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Volume 4 (2009)
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Volume 3 (2008)
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Volume 2 (2007)
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Volume 1 (2006)
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Deep Neck Infections: Decisional Algorithm for Patients with Multiple Spaces Involvement
Authors: Filippo Ricciardiello, Salvatore Mazzone, Pasquale Viola, Gianluca Guggino, Giuseppe Longo, Alberto Napolitano, Giuseppe Russo, Giulio Sequino, Flavia Oliva, Pasquale Salomone, Marco Perrella, Giovanni M. Romano, Pietro Cinaglia, Teresa Abate, Maurizio Gargiulo, Davide Pisani and Giuseppe Chiarella
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