Recent Patents on Nanotechnology - Volume 15, Issue 2, 2021

Background: About two-third of new drugs reveal low solubility in water due to which it becomes difficult for formulation scientists to develop oral solid dosage forms with a pharmaceutically acceptable range of therapeutic activity. In such cases, S-SMEEDS are the best carriers used universally for the delivery of hydrophobic drugs. SEDDS are also used but due to their limitations, SSMEDDS are used widely. These are the isotropi Read More

Polyamide (PA) Thin-Film Composite (TFC) membranes are widely used for large-scale water and wastewater treatment processes worldwide owing to their good balance between water permeability and dissolved solutes separation rate. The physicochemical properties of the cross-linked PA layer are the main criteria determining the filtration performance of the resultant TFC membrane, and this selective layer can be create Read More

Since the elucidation of the leaching process by Mizoroki in the 1970s, the research focused on this problem has increased. As a result, it has been discovered that the leached metals can not only hinder product yield, but they can also remain as contaminants of the final products. Thus, it can be concluded that metal leaching needs to be diminished or avoided more efficiently. This problem is important for the industry and the Read More

Background: Bismuth-containing nanoscale materials exhibit great application potential in catalysts, optical devices, electron devices, photo-electric devices and sensors owing to their good catalytic, optical, electric, photoelectric and sensing performance. Special research interest has been devoted to ternary bismuthate nanoscale materials due to their special layered structure, large specific surface area, excellent optical, Read More

Background: Around 40% of newly discovered chemical entities in pharmaceutical industries have poor water solubility and hence they suffer from low oral bioavailability owing to undesirable physicochemical and pharmacokinetic properties. So, it is the challenge for the formulation scientists to develop the oral formulation that can mitigate the pitfalls associated with such lipophilic drugs. Methods: Lipid nanoparticles hold a prom Read More

Background: Poor solubility and low dissolution rate limit the work at poorly water-soluble drugs like Esomeprazole. To overcome this problem, different technologies had to be used but could not resolve the problem, significantly. The main aim of this patent study was to prepare the nanocrystals using the evaporative precipitation ultrasonication method in order to improve the dissolution rate and stability of Esomepr Read More