Nanoscience & Nanotechnology-Asia - Volume 11, Issue 1, 2021

Cancer is a leading cause of mortality, and its individual and collective impact is substantial. Conventional chemotherapy utilizes drugs that effectively destroy tumour cells. However, these agents destroy healthy cells along with the tumour cells, leading to many adverse effects, which include hypersensitivity reactions, nephrotoxicity, and neurotoxicity. To minimize these adverse effects, various drug delivery systems (D Read More

To study an in-depth overview of tumor microenvironment, its target sites and the impact of nanoformulation in the modulation of tumor microenvironment specifically in the case of breast cancer as a treatment strategy. Tumor microenvironment has many sites for possible action such as extracellular matrix, acidic pH, vascular abnormalities, etc. Nanoformulation may change tumor microenvironment via targeting Read More

Aim: To propose a method of KBT synthesis at a lower temperature to solve the volatility of the components. Background: Lead-based perovskite materials have long been employed in electroceramic industries due to their excellent piezoelectric, ferroelectric, and dielectric properties. The high toxicity of lead, however, leads to the replacement of the use of lead-based perovskite in devices with more environmentally friendl Read More

Background: Cockle shell-derived calcium carbonate nanoparticles (CSCaCO3NP) are natural biogenic inorganic material that is used in drug delivery mainly as a bone-remodeling agent as well as a delivery agent for various therapeutics against bone diseases. Curcumin possesses a wide safety margin and yet puzzled with the problem of poor bioavailability due to insolubility. Propounding in vitro and in vivo studies on toxic Read More

Background: Ramipril, an antihypertensive drug exhibits 28% of oral bioavailability and is also excreted out quickly through the kidneys. Moreover, numerous side effects of Ramipril have been reported such as, hypotension (postural), increasing potassium level, and angioedema, when it is presented as an immediate dosage form. Hence, to conquer the side-effects associated with the drug and to increase its bioavailability, Read More

Background: The research work involves the development of PLGA biodegradable microspheres loaded with dexamethasone for intraocular delivery. Objective: The study aimed to design and evaluate long acting PLGA microspheres for ocular delivery of dexamethasone. Methods: The present formulation involves the development of long-acting dexamethasone loaded microspheres composed of a biodegradable contro Read More

Background: In recent years, the applications of nanoparticles have received a great attention due to their industrial and biomedical applications, while their beneficial effects suffer from controversial results at clinical stages. Objective: In the current study, cytotoxicity of cerium oxide (CeNP) nanoparticles (100 nm) were evaluated using mitochondria derived from wistar rat's liver. Methods: Isolated mitochondria from rat’s live Read More

Objective: In this study, magnetic iron oxide nanoparticles were synthesized by cost effective and an easy co-precipitation method. Methods: The effects of reaction parameters such as the mole ratio of Fe2+/Fe3+ (1/1, 1/2 and 1/3) and the base type (NaOH and NH4OH) on the average hydrodynamic diameter, zeta potential, chemical and morphological structure and saturation magnetization values of magnetic iron oxi Read More

Background and Objective: Biogenic nanomaterials are recently being researched in biomedicine for their antioxidant, antimicrobial, anti-inflammatory and antitumor performance. In this study, gold nanoparticles (AuNPs) were biologically synthesized using Nothapodytes foetida (N. foetida), a camptothecin producing plant, to evaluate its potent cytotoxic activity against cancer cells and antimicrobial activities against Read More

Introduction: Here, we present an n-channel cylindrical gate tunnel FET with drain underlap engineering (CGT-DU) and the simulation process is carried out using a 3-D device simulator from Synopsys. Methods: The analog and radio frequency (RF) performance of the device has been studied extensively in terms of the electric field, energy band analysis, drain current, gain bandwidth product, unity gain cutoff frequency, transc Read More

Background: The current research work reports an investigation of the effects of employing CuO and TiO2 nanoparticles as potential additives to refinery (petroleum) diesel fuel, in order to reduce the emissions of combustion process as well as to enhance the combustion process. Methods: Nanodiesel samples were prepared with various concentrations (50 ppm, 100 ppm, 200 ppm, 300 ppm). The experimental work was co Read More

Background: Gold nanoparticles (GNPs) have diverse optical and photo-thermal properties. It is used for diagnostic imaging because of their ability to absorb near infrared (NIR) and X-rays, and their surface enhanced Raman scattering properties. Recently they are used for drug delivery and more particularly photothermal treatment. Their ability to absorb NIR energy and convert it to heat by a Surface Plasmon Resonance m Read More

Aim: The aim of this study was to develop effective topical antifungal formulation containing sertaconazole nitrate. Background: Sertaconazole nitrate, a topical antifungal, was incorporated in solid-liquid lipid nanostructures and gelled further for topical application. Objective: The objective of this investigation was to develop a topical formulation containing sertaconazole nitrate which was incorporated in the solid-state of th Read More

Introduction: The encapsulations of phytochemical compounds within nanoparticles are attracting interest as a novel effective strategy to induce bacterial damage regardless of antibiotic sensitivity. Objective: The purpose of this study is to evaluate the antibacterial activities of different extracts of Moringa oleifera combined with alginate nanoparticles (ALg NPs) against different pathogenic bacteria. Methods: The Moring Read More