Synthetic Strategies of Pyrazoline Derivatives for the Development of New Anticancer Agents: Recent Updates

Background: Pyrazoline is a heterocyclic compound with five members, two nitrogen atoms in a circle, and one endocyclic bond. Pyrazoline is a popular electron-rich nitrogen carrier that combines exciting electronic properties with the potential for dynamic applications. Pyrazine derivatives have been synthesized using a variety of methods, all of which have shown to have a strong biological effect. Objective: The study of the biological activity of pyrazoline derivatives has been a fascinating field of pharmaceutical chemistry. Pyrazolines are used in a wide range of applications. The pyrazoline derivatives described in the literature between 2000 and 2021 were the focus of this study. Pyazolines have been discussed in terms of their introduction, general synthetic method, and anticancer potential in the current review. Conclusion: Pyrazolines are well-known heterocyclic compounds. Pyrazoline is a five-membered ring containing three carbon and two nitrogen atoms nearby. The synthesis of pyrazolines has been described using a variety of methods. Anticancer activity has been discovered in a number of pyrazoline derivatives, which encourages further research. The use of pyrazoline to treat cancer has piqued researchers' interest in learning more about this moiety.