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In the last few decades, pyrazole chemistry has attracted chemists’ and biologists’ attention mainly due to the discovery of the interesting properties of a great number of pyrazole derivatives. The resulting proliferation of research literature reflects the enormous biological potential of pyrazole derivatives as antitumor, anti-inflammatory, anti-HIV and antimicrobial agents. This review focuses on research concerning the antimicrobial activity of pyrazole derivatives conducted from 2010-2018, and is intended to assist in the development of a new generation of antimicrobial drugs.