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Lutein ((all-E,3R,3'R,6'R)-β,η-carotene-3,3'-diol) is the main carotenoid that can be found in light-harvesting complexes of higher plants and it is also involved in human diet. In the extracts of human plasma the 3'-epimer of lutein, several geometrical isomers, dehydration and oxidation products of lutein have been identified. It was also established that lutein reduces the risk of AMD (age-related macular degeneration). This mini review focuses on the in vitro and in vivo transformations of lutein.