Hybrid Bidentate Phosphoramidite Ligands in Asymmetric Catalysis

Hybrid bidentate phosphoramidite ligands are a recent family of promising phosphorus ligands. The different classes (phosphoramidite-phosphine, phosphoramidite-phosphite, phosphoramidite-phosphinite, phosphoramidite-thioethers, phosphoramidite-amine, phosphoramidite-NHC, phosphoramidite-oxazoline) are presented along with the strategies used to access to these compounds. The main part of the review summarizes the results of the evaluation of these ligands in reactions catalyzed by transition metals/bidentate phosphoramidite ligands, such as hydrogenation, hydroformylation, conjugate addition and Tsuji-Trost reaction.