Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1

Pin1, a phospho-Ser / Thr-Pro specific PPIase, participates in many biological processes. Recently, through designing substrate mimetics, or library screening, several classes of Pin1 inhibitors have been discovered. Some polyaromatic compounds, including juglone, as well as peptide mimetics containing both proline and phosphate, have been demonstrated to inhibit biological functions of Pin1.