Skip to content
2000
Volume 24, Issue 5
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

DNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3A discovered in recent years and their inhibitory activities, and classified them based on their inhibitory mechanisms.

Loading

Article metrics loading...

/content/journals/mrmc/10.2174/1389557523666230825100246
2024-03-01
2024-12-23
Loading full text...

Full text loading...

/content/journals/mrmc/10.2174/1389557523666230825100246
Loading

  • Article Type:
    Research Article
Keyword(s): cancer; DNMT; DNMT inhibitors; DNMT3A; epigenetic modification; SAM
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test