Skip to content
2000
Volume 21, Issue 12
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Memory remains an obligatory regime of the human brain, and impaired memory causes serious obstacles in our everyday life. Alzheimer’s disease (AD) is one such neurodegenerative disease which mostly affects the elderly population, above the age of 60; marked by cognitive impairment of memory. Besides the known targets of AD against the several etiologies known to date, the zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not affect DNA sequence but only long-term gene expression. Considering the complex multifactorial nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic approaches. We reviewed the possible epigenetic targets for AD-like HDAC, Sirtuins, glial cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target areas can surely evolve AD diagnosis and therapeutics.

Loading

Article metrics loading...

/content/journals/mrmc/10.2174/1389557521999201228191427
2021-07-01
2025-07-09
Loading full text...

Full text loading...

/content/journals/mrmc/10.2174/1389557521999201228191427
Loading

  • Article Type:
    Review Article
Keyword(s): Alzheimer’s; Dicer; DNA methylation; epigenetics; glial cell; HDACs; MiRNA; sirtuins
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test