Skip to content
2000
Volume 17, Issue 12
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Background: Terpenoids are hydrocarbon compounds derived from common five-carbon isoprene (CH) building blocks. They are formed through the condensation and subsequent modification of isoprene units in various ways including 128;“ among others 128;“ cyclization and/or oxygenation. Their synthesis is localized either to the chloroplast and/or to the cytoplasm/peroxisome/endoplasmic reticulum and mitochondrion. Terpenoids represent a very large and diverse class of metabolites and play important roles in plant growth and development. In addition, they have been intensively used in human health care, disease treatment and in dietary supplements. Approximately 60% of natural products known so far are terpenoids. Results and Discussion: This review briefly summarizes the biosynthetic pathways of major plant terpenoids. Then, five well-known and medicinally important diterpenoids, including paclitaxel, tanshinone, ginkgolide, triptolide and oridonin are discussed in detail. Their structures, occurrence, extraction and identification methods, pharmacological properties and clinical uses are also reviewed. Finally, the prospects of using biotechnology to produce medicinally important terpenoids are also briefly discussed.

Loading

Article metrics loading...

/content/journals/mrmc/10.2174/1389557516666160614005244
2017-08-01
2025-07-04
Loading full text...

Full text loading...

/content/journals/mrmc/10.2174/1389557516666160614005244
Loading

  • Article Type:
    Research Article
Keyword(s): Diterpenoid; ginkgolide; oridonin; paclitaxel; plastid; tanshinone; triptolide
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test