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2000
Volume 13, Issue 11
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Authorities of Drug Administration in the United States of America approved about 5000 drugs for use in the therapy or management of several diseases. About two hundred of these drugs have active metabolites and the knowledge of their medicinal chemistry is important both in medical practice and pharmaceutical research. This review gives a detailed description of the medicinal chemistry of drugs with active metabolites generated after conjugation. This review focused on glucuronide-, acetyl-, sulphate- and phosphate-conjugation of drugs, converting the drug into an active metabolite. This conversion essentially changed the lipophilicity of the drug.

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/content/journals/mrmc/10.2174/1389557511313110002
2013-10-01
2024-11-02
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