Skip to content
2000
Volume 13, Issue 9
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

During the last 4 decades, intensive research has focussed on the effect of small organic molecules with antitumour activity that are able to intercalate into DNA and inhibit topoisomerase and telomerase enzymes. In this review, we describe some of the chemical and biological properties of acridine, which is a chemotherapeutic agent that has been used for cancer treatment since 1970. In addition, we summarise the progress that has been made in the development of anticancer agents based on the clinical in vivo/in vitro studies that have been conducted for 13 classes of natural and synthetic acridines.

Loading

Article metrics loading...

/content/journals/mrmc/10.2174/1389557511313090002
2013-07-01
2025-02-26
Loading full text...

Full text loading...

/content/journals/mrmc/10.2174/1389557511313090002
Loading

  • Article Type:
    Research Article
Keyword(s): Acridine; Anticancer; Antitumour; Chemotherapy; DNA intercalation; Topoisomerases
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test