oa EDITORIAL [Hot Topic: QSAR and Computer Aided Drug Design (Guest Editor: Mahmud Tareq Hassan Khan)]

I am very much thrilled to see the complete version of my target as the Guest Editor for Hot Topic issue entitled, “QSAR and Computer Aided Drug Design” for the journal ‘Mini-Reviews in Medicinal Chemistry (MRMC)’. Under this umbrella I had the aim to cover most important areas of structure- (SB) and ligand-based (LB) computer-aided drug design including, recent developments in rational drug design, molecular modelling, quantitative structure-activity relationship (QSAR), QRAR (Quantitative Retention-Activity Relationship), pharmacophore modelling, etc., targeting different diseases & disease conditions, like Alzheimer's disease (AD), HIV, neurodegenerative disorders, depression, malaria, etc. The volume composed of twelve articles from the experts in the field. In the 1st article Ibrahim and co-workers explained different QSAR and molecular modelling approaches on developing some fullerene derivatives as anti-HIV protease inhibitors. Prado and Garcia, in their article discussed about different approaches of QSAR, like CoMFA, CoMSIA, etc., and molecular modeling, like docking, of the molecules against Alzheimer's disease (AD) particular targeting β and γ-secretase inhibitors. Authors in their article also reviewed about the similar approaches utilized for the targets like GSK-3α and GSK-3β....