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2000
Volume 9, Issue 12
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.

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/content/journals/mrmc/10.2174/138955709789957422
2009-10-01
2025-02-28
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