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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Treating Age-Related Macular Degeneration - Interaction of VEGF-Antagonists with their Target
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 9, Aug 2009, p. 1127 - 1135
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- 01 Aug 2009
Abstract
The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and -Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.
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