Full text loading...
- ISSN: 1389-5575
- E-ISSN: 1875-5607
-
Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 9, Aug 2009, p. 1075 - 1083
-
- 01 Aug 2009
Abstract
The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.
© Bentham Science Publishers