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2000
Volume 8, Issue 12
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Reverse transcription is a crucial step in the life cycle of human immunodeficiency virus type 1 (HIV-1). In this process, multiple functional enzymes including RNA-dependent DNA polymerase, DNA-dependent DNA polymerase and RNase H are indispensable. The RNase H functions to degrade RNA of the RNA-DNA heteroduplex into small fragment. These properties of HIV-1 RNase H make it an attractive target for rational anti-HIV-1 drug design and development. In this review, we summarized the HIV-1 RNase H inhibitors that were recently reported in the literature, including their chemical structure, mechanism and structure-activity relationship. It seems likely that HIV-1 RNase H as a prominent non-traditional target may lead to the development of anti-HIV agents which could be used alone or in the combination with other HIV inhibitors in AIDS chemotherapy.

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/content/journals/mrmc/10.2174/138955708786141052
2008-10-01
2025-06-28
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  • Article Type:
    Research Article
Keyword(s): AIDS; HIV-1; mechanism; RNase H inhibitor; SAR
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