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2000
Volume 8, Issue 9
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Asthma is a chronic heterogeneous inflammatory disease of the respiratory system in which numerous cytokines play a significant role. Among them TNF-α (tumour necrosis factor α), a proinflammatory cytokine, has a predominant role in orchestrating airway inflammation and affecting treatment outcome. In this review we attempt to summarize the involvement of TNF-α in the pathogenesis of asthma, illustrate variations of TNF-α gene that potentially influence asthma phenotype and highlight promising therapies by blocking the production of TNF-α or inhibiting its action. A cytokine specific target therapy seems to be very promising since agents that block TNF-α slow disease progression, suppress inflammation and in some cases induce remission of chronic inflammation.

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/content/journals/mrmc/10.2174/138955708785132828
2008-08-01
2025-10-01
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/content/journals/mrmc/10.2174/138955708785132828
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  • Article Type:
    Research Article
Keyword(s): Asthma; chronic heterpgeneous disease; chronic inflammation; inflammatory disease; TNF
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