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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Combretastatin A-4 Analogs as Anticancer Agents
- Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 12, Dec 2007, p. 1186 - 1205
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- 01 Dec 2007
Abstract
Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.
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