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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Peroxisome Proliferator-Activated Receptor Agonists as Potential Therapeutic Agents in Multiple Sclerosis
- Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 11, Nov 2007, p. 1129 - 1135
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- 01 Nov 2007
Abstract
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for gene regulation in glucose and lipid metabolism. It has been recently implicated that PPARs regulate cellular proliferation and inflammatory responses; some agonists for PPARs ameliorate experimental autoimmune encephalomyelitis, a model of multiple sclerosis (MS) in humans. This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS.
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