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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimer's Disease
- Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 10, Oct 2007, p. 1001 - 1008
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- 01 Oct 2007
Abstract
Senile plaques in the brain of patients with Alzheimer's disease mainly consist of aggregates of amyloid β peptides (Aβ42, Aβ40). Aβ42 is more neurotoxic than Aβ40. This review describes recent findings from a structural analysis of Aβ42 aggregates and discusses their relevance to neurotoxicity through the formation of radicals.
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