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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Depsipeptide (FK228) as a Novel Histone Deacetylase Inhibitor: Mechanism of Action and Anticancer Activity
- Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 10, Oct 2007, p. 1062 - 1069
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- 01 Oct 2007
Abstract
Depsipeptide (FK228), a new histone deacetylase inhibitor, has been recently introduced into clinical trials. This agent shows interesting metabolic properties, novel mechanism of action, and is undergoing phase I-II clinical studies in hematopoietic malignancies and solid tumors. Mechanism of action, pharmacokinetics and anticancer activity of depsipeptide is the subject of this review.
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