Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD)

Using analytical microscopies we have observed an increase of Fe2+ iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific agingdependent pathogenic event responsible for neurodegenerative disease.