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2000
Volume 7, Issue 8
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.

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/content/journals/mrmc/10.2174/138955707781387867
2007-08-01
2025-07-06
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