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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Somatostatin sst4 Ligands: Chemistry and Pharmacology
- Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 3, Mar 2007, p. 213 - 220
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- 01 Mar 2007
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Abstract
Several classes of compounds (thioureas, ureas, β-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.
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