Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing

A. Bitto; L. Minutoli; F. Squadrito; F. Polito; D. Altavilla

doi:10.2174/138955707780059835

ISSN: 1389-5575
E-ISSN: 1875-5607

Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing
Authors: A. Bitto¹, L. Minutoli², F. Squadrito³, F. Polito⁴ and D. Altavilla⁵
View Affiliations Hide Affiliations

¹ the Section of Pharmacology,Department of Experimental, And Clinical Medicine and Pharmacology,Torre Biologica 5th floor, “AOU” Policlinico G. Martino, Via C. Valeria Gazzi, 98124 Messina, Italy. ² the Section of Pharmacology,Department of Experimental, And Clinical Medicine and Pharmacology,Torre Biologica 5th floor, “AOU” Policlinico G. Martino, Via C. Valeria Gazzi, 98124 Messina, Italy. ³ the Section of Pharmacology,Department of Experimental, And Clinical Medicine and Pharmacology,Torre Biologica 5th floor, “AOU” Policlinico G. Martino, Via C. Valeria Gazzi, 98124 Messina, Italy. ⁴ the Section of Pharmacology,Department of Experimental, And Clinical Medicine and Pharmacology,Torre Biologica 5th floor, “AOU” Policlinico G. Martino, Via C. Valeria Gazzi, 98124 Messina, Italy. ⁵ the Section of Pharmacology,Department of Experimental, And Clinical Medicine and Pharmacology,Torre Biologica 5th floor, “AOU” Policlinico G. Martino, Via C. Valeria Gazzi, 98124 Messina, Italy.
Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 3, Mar 2007, p. 339 - 343
DOI: https://doi.org/10.2174/138955707780059835
- Available online: 01 Mar 2007

Abstract

Raxofelast, also named IRFI 016 or (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid, belongs to a family of novel molecules designed with the aim to maximize antioxidant potency of phenols related to Vitamin E ( α-tocopherol). This review will focus on the antioxidant and radical scavenging activity of this new promising compound.

Article metrics loading...

/content/journals/mrmc/10.2174/138955707780059835

2007-03-01

2025-07-03

From This Site

/content/journals/mrmc/10.2174/138955707780059835

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/mrmc/10.2174/138955707780059835

Article Type: Research Article

Keyword(s): diabetes; inflammation; ischemia/reperfusion injury; Raxofelast; safety; wound healing

Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

Imidazoles as Potential Antifungal Agents: A Review

Structure-Function Relationships in Chloroquine and Related 4-Aminoquinoline Antimalarials

Small Molecule Inhibitors of Serine Threonine Protein Phosphatases

DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs

Recent Advances in Bioreductive Drug Targeting

Structure-Metabolism Relationships Steric Effects and the Enzymatic Hydrolysis of Carboxylic Esters

Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System

Recent Advances in the Synthesis of Tubulysins