Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Ellen L. Crossley; Erin J. Ziolkowski; Jeffrey A. Coderre; Louis M. Rendina

doi:10.2174/138955707780059808

ISSN: 1389-5575
E-ISSN: 1875-5607

Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy
Authors: Ellen L. Crossley¹, Erin J. Ziolkowski², Jeffrey A. Coderre³ and Louis M. Rendina⁴
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¹ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ² School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ³ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ⁴ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 3, Mar 2007, p. 303 - 313
DOI: https://doi.org/10.2174/138955707780059808
- Available online: 01 Mar 2007

Abstract

Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.

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2007-03-01

2025-07-24

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Article Type: Research Article

Keyword(s): Boron neutron capture therapy; boronated agent; boronic acid; carborane; DNA-targeting

Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Abstract

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