Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Ellen L. Crossley; Erin J. Ziolkowski; Jeffrey A. Coderre; Louis M. Rendina

doi:10.2174/138955707780059808

ISSN: 1389-5575
E-ISSN: 1875-5607

Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy
Authors: Ellen L. Crossley¹, Erin J. Ziolkowski², Jeffrey A. Coderre³ and Louis M. Rendina⁴
View Affiliations Hide Affiliations

¹ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ² School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ³ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ⁴ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 3, Mar 2007, p. 303 - 313
DOI: https://doi.org/10.2174/138955707780059808
- Available online: 01 Mar 2007

Abstract

Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.

Article metrics loading...

/content/journals/mrmc/10.2174/138955707780059808

2007-03-01

2025-07-06

From This Site

/content/journals/mrmc/10.2174/138955707780059808

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/mrmc/10.2174/138955707780059808

Article Type: Research Article

Keyword(s): Boron neutron capture therapy; boronated agent; boronic acid; carborane; DNA-targeting

Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

Imidazoles as Potential Antifungal Agents: A Review

Structure-Function Relationships in Chloroquine and Related 4-Aminoquinoline Antimalarials

Small Molecule Inhibitors of Serine Threonine Protein Phosphatases

DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs

Recent Advances in Bioreductive Drug Targeting

Structure-Metabolism Relationships Steric Effects and the Enzymatic Hydrolysis of Carboxylic Esters

Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System

Recent Advances in the Synthesis of Tubulysins