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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Adenosine-to-Inosine RNA Editing: Perspectives and Predictions
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 11, Nov 2006, p. 1213 - 1216
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- 01 Nov 2006
Abstract
Adenosine-to-Inosine RNA editing introduces changes in RNA transcripts via a post-transcriptional mechanism, the hydrolytic deamination of adenosine (A) to inosine (I) which is interpreted as guanosine by cellular machineries. Adenosine deaminases that act on RNA (ADAR) enzymes catalyze editing in double-stranded (ds) RNA substrates.
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