Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration

Maria L. Bolognesi; Anna Minarini; Vincenzo Tumiatti; Carlo Melchiorre

doi:10.2174/138955706778742731

ISSN: 1389-5575
E-ISSN: 1875-5607

Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration
Authors: Maria L. Bolognesi¹, Anna Minarini², Vincenzo Tumiatti³ and Carlo Melchiorre⁴
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¹ Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. ² Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. ³ Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. ⁴ Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 11, Nov 2006, p. 1269 - 1274
DOI: https://doi.org/10.2174/138955706778742731
- Available online: 01 Nov 2006

Abstract

Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic factors. Recent research into new drugs, which are able to hit different targets, highlights the idea that a single molecule could be sufficient to treat multi-factorial diseases. In this review, examples of multi-target-directed compounds derived from lipoic acid are examined.

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2006-11-01

2025-06-23

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Article Type: Research Article

Keyword(s): Antioxidants; Lipoic acid; Multi-target-directed drugs; Neurodegenerative diseases; Reactive oxygen species

Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration

Abstract

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