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2000
Volume 6, Issue 10
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.

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/content/journals/mrmc/10.2174/138955706778560184
2006-10-01
2025-07-07
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