Synthesis and Biological Activity of Akt/PI3K Inhibitors

C. Redaelli; F. Granucci; L. De Gioia; L. Cipolla

doi:10.2174/138955706778560139

ISSN: 1389-5575
E-ISSN: 1875-5607

Synthesis and Biological Activity of Akt/PI3K Inhibitors
Authors: C. Redaelli¹, F. Granucci², L. De Gioia³ and L. Cipolla⁴
View Affiliations Hide Affiliations

¹ Department of Biotechnology and Biosciences, University of Milano-Bicocca, I-20126 Milano, Italy. ² Department of Biotechnology and Biosciences, University of Milano-Bicocca, I-20126 Milano, Italy. ³ Department of Biotechnology and Biosciences, University of Milano-Bicocca, I-20126 Milano, Italy. ⁴ Department of Biotechnology and Biosciences, University of Milano-Bicocca, I-20126 Milano, Italy.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 10, Oct 2006, p. 1127 - 1136
DOI: https://doi.org/10.2174/138955706778560139
- Available online: 01 Oct 2006

Abstract

Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.

Article metrics loading...

/content/journals/mrmc/10.2174/138955706778560139

2006-10-01

2025-06-26

From This Site

/content/journals/mrmc/10.2174/138955706778560139

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/mrmc/10.2174/138955706778560139

Article Type: Research Article

Keyword(s): Akt; allosteric inhibitors; cancer; kinase inhibitors; Kinases; phosphatidylinositol; phosphatidylinositol analogues; PI3K

Synthesis and Biological Activity of Akt/PI3K Inhibitors

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

Imidazoles as Potential Antifungal Agents: A Review

Structure-Function Relationships in Chloroquine and Related 4-Aminoquinoline Antimalarials

Small Molecule Inhibitors of Serine Threonine Protein Phosphatases

DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs

Recent Advances in Bioreductive Drug Targeting

Structure-Metabolism Relationships Steric Effects and the Enzymatic Hydrolysis of Carboxylic Esters

Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System

Recent Advances in the Synthesis of Tubulysins