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2000
Volume 6, Issue 10
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.

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/content/journals/mrmc/10.2174/138955706778560120
2006-10-01
2025-07-27

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  • Article Type:     Research Article
Keyword(s): marketed drugs; Organosilicon chemistry; silicon switch; validated targets

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