Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors

Anastassios Vourekas; Dimitra Kalavrizioti; Constantinos Stathopoulos; Denis Drainas

doi:10.2174/138955706778195199

ISSN: 1389-5575
E-ISSN: 1875-5607

Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors
Authors: Anastassios Vourekas¹, Dimitra Kalavrizioti², Constantinos Stathopoulos³ and Denis Drainas⁴
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¹ Department of Biochemistry, School of Medicine, University of Patras, 265 04 Patras, Greece. ² Department of Biochemistry, School of Medicine, University of Patras, 265 04 Patras, Greece. ³ Department of Biochemistry, School of Medicine, University of Patras, 265 04 Patras, Greece. ⁴ Department of Biochemistry, School of Medicine, University of Patras, 265 04 Patras, Greece.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 9, Sep 2006, p. 971 - 978
DOI: https://doi.org/10.2174/138955706778195199
- Available online: 01 Sep 2006

Abstract

Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are capable of serving as a new molecular target for a variety of drugs and as a reliable screening system for their biological activity.

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2006-09-01

2025-07-26

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Article Type: Research Article

Keyword(s): aminoglycosides; calcipotriol; drug target; macrolides; retinoids; ribosome; Ribozymes; RNase P

Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors

Abstract

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