The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases

Hirokazu Tamamura; Hiroshi Tsutsumi; Nobutaka Fujii

doi:10.2174/138955706778195135

ISSN: 1389-5575
E-ISSN: 1875-5607

The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases
Authors: Hirokazu Tamamura¹, Hiroshi Tsutsumi² and Nobutaka Fujii³
View Affiliations Hide Affiliations

¹ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku,Tokyo 101-0062, Japan. ² Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku,Tokyo 101-0062, Japan. ³ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku,Tokyo 101-0062, Japan.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 9, Sep 2006, p. 989 - 995
DOI: https://doi.org/10.2174/138955706778195135
- Available online: 01 Sep 2006

Abstract

CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12- CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA). Thus, CXCR4 is thought to be an important therapeutic target to overcome the above diseases. We have developed several specific CXCR4 antagonists.

Article metrics loading...

/content/journals/mrmc/10.2174/138955706778195135

2006-09-01

2025-07-10

From This Site

/content/journals/mrmc/10.2174/138955706778195135

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/mrmc/10.2174/138955706778195135

Article Type: Research Article

Keyword(s): cancer metastasis; chemokine receptor; HIV infection; Leukemia cell progression; low molecular weight CXCR4 antagonist; rheumatoid arthritis; T140; T22

The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

Imidazoles as Potential Antifungal Agents: A Review

Structure-Function Relationships in Chloroquine and Related 4-Aminoquinoline Antimalarials

Small Molecule Inhibitors of Serine Threonine Protein Phosphatases

DNA Tetraplex-Binding Drugs Structure-Selective Targeting is Critical for Antitumour Telomerase Inhibition

Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs

Recent Advances in Bioreductive Drug Targeting

Structure-Metabolism Relationships Steric Effects and the Enzymatic Hydrolysis of Carboxylic Esters

Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System

Recent Advances in the Synthesis of Tubulysins