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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Leptin, Estrogens and Cancer
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 8, Aug 2006, p. 897 - 907
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- 01 Aug 2006
Abstract
Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.
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