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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 7, Jul 2006, p. 805 - 815
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- 01 Jul 2006
Abstract
NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.
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