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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 5, May 2006, p. 575 - 581
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- 01 May 2006
Abstract
More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.
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