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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues
- Source: Mini Reviews in Medicinal Chemistry, Volume 5, Issue 1, Jan 2005, p. 1 - 12
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- 01 Jan 2005
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Abstract
Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward “normal” and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.
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