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Extrahepatic and Circulating miR-122: Diagnostic Implications and Future Directions
Authors: Rachel Sarah Royfman, Joseph Riley Mctague, Meghana Ranabothu and Bindu MenonAvailable online: 23 January 2025More LessResearch on microRNAs is constantly expanding and evolving due to their role in the regulation of gene expression. miR-122, a 22-nucleotide microRNA, was first discovered as a liver-specific miRNA. Subsequently, it was found to be present in a wide range of tissues, such as the breast, testes, ovaries, and heart. The research on miR-122 in the liver has been extensive over the past few decades, leading to several import Read More
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micro-RNA 451-a as a Circulating Biomarker for Neuroblastoma
Available online: 10 January 2025More LessIntroduction Micro ribonucleic acids (miRNAs) are small non-coding RNAs that modulate the expression of various genes. They have an important role in cancer pathogenesis. Differential expression of multiple miRNAs have been used as potential diagnostic and prognostic markers. Methods Various cancers have lately been employed as therapeutic targets. This prospective study included untreated pediatric neuroblastoma ( Read More
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The Role of Noncoding RNAs in the Prognosis and Diagnosis of Colorectal Cancer: An Emerging Biomarker
Authors: O. Surekha Vani, Kavitha R Thangaraj, Varshaa Ravichandran and Solomon F. D PaulAvailable online: 26 November 2024More LessColorectal cancer has become the leading cause of death worldwide, and it is the second most common cancer in women and the third most common cancer in men. Accumulating evidence suggests that genetic and epigenetic factors play a key role in the development of colorectal cancer. Cancer Stem Cells (CSC) play an important role in the suppression or development of cancer in various conditions. In recent yea Read More
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Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing
Authors: Bhawna Sharma, Iti Chauhan, Gaurav Kumar, Khushboo Bhardwaj and Raj Kumar TiwariAvailable online: 31 October 2024More LessThe revolutionary CRISPR/Cas9 gene editing technology holds immense potential for treating genetic diseases and tackling conditions like cancer. However, efficient delivery remains a significant challenge. This is where nanoparticles come into play, emerging as powerful allies in the realm of drug delivery. Nanoparticles can accommodate larger insertion sizes, enabling the incorporation of larger Cas9 enzymes and complex g Read More
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