Skip to content
2000
  1. Home
  2. A-Z Publications
  3. MicroRNA
  4. Fast Track Articles
  5. Fast Track Article
image of The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review

Abstract

Introduction

Curcumin is known as a bioactive component that is found in the rhizomes of Curcuma longa. Curcumin is well known for its chemo-preventive and anticancer properties. However, its anticancer mechanism in colorectal cancer treatment is unclear, and some studies have shown that many microRNAs (miRs) could be potential targets for curcumin in colorectal cancer (CRC) treatment, so there is a need for their integration and clarification.

Methods

We systematically searched international databases, including PubMed, Scopus, and Web of Science, until July 2021 by using some relevant keywords.

Results

The search resulted in 87 papers, among which there were 18 related articles. Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR‐34, miR‐126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a and the downregulation of miR-21, miR-155, miR‐221, miR‐222, miR-17-5p, miR-130a, miR-27, and miR-20a.

Conclusion

The present review study suggests that curcumin may be useful as a novel therapeutic agent for CRC by altering the expression level of miRs.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/mirna/10.2174/0122115366304114240904051429
2024-09-12
2024-11-23

  • From This Site

    /content/journals/mirna/10.2174/0122115366304114240904051429
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Biller L.H. Schrag D. Diagnosis and treatment of metastatic colorectal cancer: A review. JAMA 2021 325 7 669 685 10.1001/jama.2021.0106 33591350
    [Google Scholar]
  2. Hashiguchi Y. Muro K. Saito Y. Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int. J. Clin. Oncol. 2020 25 1 1 42 10.1007/s10147‑019‑01485‑z 31203527
    [Google Scholar]
  3. Amalraj A. Pius A. Gopi S. Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their de-rivatives – A review. J. Tradit. Complement. Med. 2017 7 2 205 233 10.1016/j.jtcme.2016.05.005 28417091
    [Google Scholar]
  4. Rodrigues F.C. Anil Kumar N.V. Thakur G. Developments in the anticancer activity of structurally modified curcumin: An up-to-date review. Eur. J. Med. Chem. 2019 177 76 104 10.1016/j.ejmech.2019.04.058 31129455
    [Google Scholar]
  5. Ismail N.I. Othman I. Abas F.H. Lajis N. Naidu R. Mechanism of apoptosis induced by curcumin in colorectal cancer. Int. J. Mol. Sci. 2019 20 10 2454 10.3390/ijms20102454 31108984
    [Google Scholar]
  6. Wang H. Cai X. Ma L. Curcumin modifies epithelial–mesenchymal transition in colorectal cancer through regulation of miR-200c/EPM5. Cancer Manag. Res. 2020 12 9405 9415 10.2147/CMAR.S260129 33061628
    [Google Scholar]
  7. Okugawa Y. Grady W.M. Goel A. Epigenetic alterations in colorectal cancer: Emerging biomarkers. Gastroenterology 2015 149 5 1204 1225 10.1053/j.gastro.2015.07.011
    [Google Scholar]
  8. Moher D. Shamseer L. Clarke M. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst. Rev. 2015 4 1 1 9 10.1186/2046‑4053‑4‑1 25554246
    [Google Scholar]
  9. Mudduluru G. George-William J.N. Muppala S. Curcumin regulates miR-21 expression and inhibits invasion and metas-tasis in colorectal cancer. Biosci. Rep. 2011 31 3 185 197 10.1042/BSR20100065 20815812
    [Google Scholar]
  10. Michael M.Z. O’ Connor S.M. van Holst Pellekaan N.G. Young G.P. James R.J. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol. Cancer Res. 2003 1 12 882 891 14573789
    [Google Scholar]
  11. Zhao P. Zhang C. Xie D. Pei M. Curcumin inhibits epithelial-mesenchymal transition in colorectal cancer cells by regulating miR-206/SNAI2 pathway. Trop. J. Pharm. Res. 2021 18 7 1405 1412 10.4314/tjpr.v18i7.6
    [Google Scholar]
  12. Toden S. Okugawa Y. Buhrmann C. Novel evidence for curcumin and boswellic acid–induced chemoprevention through regulation of miR-34a and miR-27a in colorectal can-cer. Cancer Prev. Res. 2015 8 5 431 443 10.1158/1940‑6207.CAPR‑14‑0354 25712055
    [Google Scholar]
  13. Akbari A. Sedaghat M. Heshmati J. Molecular mecha-nisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers. Biomed. Pharmacother. 2021 141 111849 10.1016/j.biopha.2021.111849 34214729
    [Google Scholar]
  14. Gavrilas L. Ionescu C. Tudoran O. Lisencu C. Balacescu O. Miere D. The role of bioactive dietary components in modu-lating miRNA expression in colorectal cancer. Nutrients 2016 8 10 590 10.3390/nu8100590 27681738
    [Google Scholar]
  15. Zhang H. Xu W. Li B. Curcumin promotes cell cycle arrest and inhibits survival of human renal cancer cells by negative modulation of the PI3K/AKT signaling pathway. Cell Biochem. Biophys. 2015 73 3 681 686 10.1007/s12013‑015‑0694‑5 27259310
    [Google Scholar]
  16. Tazawa H. Tsuchiya N. Izumiya M. Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon can-cer cells. Proc. Natl. Acad. Sci. USA 2007 104 39 15472 15477 10.1073/pnas.0707351104 17875987
    [Google Scholar]
  17. Chen H.J. Hsu L.S. Shia Y.T. Lin M.W. Lin C.M. The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway. Biochem. Pharmacol. 2012 84 9 1143 1153 10.1016/j.bcp.2012.08.011 22935447
    [Google Scholar]
  18. Sadoughi F. Maleki Dana P. Asemi Z. Yousefi B. Targeting microRNAs by curcumin: Implication for cancer therapy. Crit. Rev. Food Sci. Nutr. 2021 1 12 33905266
    [Google Scholar]
  19. Toden S. Okugawa Y. Jascur T. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis 2015 36 3 355 367 10.1093/carcin/bgv006 25653233
    [Google Scholar]
  20. Zheng Z. You H. Feng Y. Zhang Z. LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin re-sistance in the colorectal cancer cells. Mol. Cell. Biochem. 2021 476 7 2575 2585 10.1007/s11010‑020‑03856‑x 32757174
    [Google Scholar]
  21. Han W. Yin H. Ma H. Wang Y. Kong D. Fan Z. Curcumin regulates ERCC1 expression and enhances oxaliplatin sensi-tivity in resistant colorectal cancer cells through its effects on miR-409-3p. Evid. Based Complement. Alternat. Med. 2020 2020 8394574 10.1155/2020/8394574
    [Google Scholar]
  22. Pakizehkar S. Ranji N. Sohi A.N. Sadeghizadeh M. Poly-mersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells. Polym. Adv. Technol. 2020 31 1 160 177 10.1002/pat.4759
    [Google Scholar]
  23. Reimondez-Troitiño S. González-Aramundiz J.V. Ruiz-Bañobre J. Versatile protamine nanocapsules to restore miR-145 levels and interfere tumor growth in colorectal cancer cells. Eur. J. Pharm. Biopharm. 2019 142 449 459 10.1016/j.ejpb.2019.07.016 31326581
    [Google Scholar]
  24. Tang J. Yang J. Curcumin inhibits viability and promotes apoptosis by modulating miR-17/caspase-9 pathway in colo-rectal cancer. Trop. J. Pharm. Res. 2019 18 12
    [Google Scholar]
  25. Li B. Shi C. Li B. Zhao J.M. Wang L. The effects of Curcumin on HCT‐116 cells proliferation and apoptosis via the miR‐491/PEG10 pathway. J. Cell. Biochem. 2018 119 4 3091 3098 10.1002/jcb.26449 29058812
    [Google Scholar]
  26. Dou H. Shen R. Tao J. Curcumin suppresses the colon cancer proliferation by inhibiting Wnt/β-catenin pathways via miR-130a. Front. Pharmacol. 2017 8 877 10.3389/fphar.2017.00877 29225578
    [Google Scholar]
  27. Roy S. Yu Y. Padhye S.B. Sarkar F.H. Majumdar A.P.N. Difluor-inated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21. PLoS One 2013 8 7 e68543 10.1371/journal.pone.0068543 23894315
    [Google Scholar]
  28. Yu Y. Sarkar F.H. Majumdar A.P.N. Down-regulation of miR-21 induces differentiation of chemoresistant colon cancer cells and enhances susceptibility to therapeutic regimens. Transl. Oncol. 2013 6 2 180 186 10.1593/tlo.12397 23544170
    [Google Scholar]
  29. Noratto G.D. Jutooru I. Safe S. Angel-Morales G. Mertens-Talcott S.U. The drug resistance suppression induced by cur-cuminoids in colon cancer SW ‐480 cells is mediated by reac-tive oxygen species‐induced disruption of the micro RNA ‐27a‐ ZBTB 10‐ S p axis. Mol. Nutr. Food Res. 2013 57 9 1638 1648 10.1002/mnfr.201200609 23471840
    [Google Scholar]
  30. Gandhy S.U. Kim K. Larsen L. Rosengren R.J. Safe S. Curcu-min and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by tar-geting microRNAs. BMC Cancer 2012 12 1 564 10.1186/1471‑2407‑12‑564 23194063
    [Google Scholar]
  31. Roy S. Levi E. Majumdar A.P.N. Sarkar F.H. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J. Hematol. Oncol. 2012 5 1 58 10.1186/1756‑8722‑5‑58 22992310
    [Google Scholar]
  32. Adeyeni T Vattathara K Duggirala R Selvamani V Ezekiel U. Curcumin inhibits DLD‐1 colorectal cancer cell proliferation by modulating microRNA and tumor suppressor gene expression. FASEB J 2015 29 721.8
    [Google Scholar]
/content/journals/mirna/10.2174/0122115366304114240904051429
Loading
The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
Bentham Science Publishers ; https://doi.org/10.2174/0122115366304114240904051429
/content/journals/mirna/10.2174/0122115366304114240904051429
/content/journals/mirna/10.2174/0122115366304114240904051429
Loading

Data & Media loading...

Supplements

file format download Download

  • Article Type:     Review Article
Keywords: Curcuma longa ; Systematic Review ; Curcumin ; Micro RNA ; miRNA ; Colorectal cancer
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test