MicroRNA Biomarkers on Day of Injury Among Patients with Post Concussive Symptoms at 28-Days: A Prospective Cohort Study

Biswadev Mitra; Brendan Major; Jonathan Reyes; Nanda Surendran; Jesse Bain; Lauren P. Giesler; William T. O’Brien; Edmond Sorich; Catherine Willmott; Sandy R. Shultz; Terence J. O’Brien; Jeffrey V. Rosenfeld; Stuart J. McDonald

doi:10.2174/0122115366297817240613065052

ISSN: 2211-5366
E-ISSN: 2211-5374

MicroRNA Biomarkers on Day of Injury Among Patients with Post Concussive Symptoms at 28-Days: A Prospective Cohort Study
Authors: Biswadev Mitra^1,2, Brendan Major³, Jonathan Reyes^4,5,6, Nanda Surendran¹, Jesse Bain³, Lauren P. Giesler³, William T. O’Brien³, Edmond Sorich⁷, Catherine Willmott^4,5,6, Sandy R. Shultz^3,8, Terence J. O’Brien³, Jeffrey V. Rosenfeld^9,10 and Stuart J. McDonald³
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Affiliations: ¹ Emergency & Trauma Centre, The Alfred Hospital, Melbourne, VIC, Australia ; ² School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC, Australia ; ³ Department of Neuroscience, The School of Translational Medicine, Monash University, Melbourne, VIC, Australia ; ⁴ Monash-Epworth Rehabilitation Research Centre (MERRC), Epworth Hospital, Melbourne, VIC, Australia ; ⁵ School of Psychological Sciences, Monash University, Melbourne, VIC, 3004, Australia ; ⁶ Australian Football League, Melbourne, VIC, Australia ; ⁷ Glia Diagnostics, Neutral Bay, NSW, Australia; ⁸ Centre for Trauma and Mental Health Research, Vancouver Island University, Nanaimo, BC, Canada ; ⁹ Department of Neurosurgery, The Alfred Hospital, Melbourne, VIC; ¹⁰ Department of Surgery, Monash University, Melbourne, VIC, Australia
Source: MicroRNA, Volume 13, Issue 3, Nov 2024, p. 233 - 239
DOI: https://doi.org/10.2174/0122115366297817240613065052
- Received: 15 Feb 2024
- Accepted: 16 May 2024
- Available online: 01 Nov 2024

Abstract

Background

After mild traumatic brain injury (mTBI), some patients experience symptoms that persist for weeks to months. Recovery from mTBI is primarily assessed using self-reported symptom questionnaires. Blood biomarkers, including microRNA species, have shown promise to assist diagnosis of mTBI, however, little is known about how blood microRNA measures might predict symptom recovery.

Objective

The aim of this study was to investigate the variances in plasma microRNAs on the day of injury between individuals with mTBI who report post-concussive symptoms at the 28-day mark and those who do not.

Methods

Patients who presented to an adult, tertiary referral hospital emergency department on the day of the injury and were diagnosed with isolated mTBI (n=35) were followed up for 28 days. Venous blood samples were collected and symptom severity was assessed using the Rivermead Post-Concussion Symptom Questionnaire (RPQ) on the day of injury and at 28 days. Patients who reported ongoing symptoms of total RPQ score ≥10 or at least one symptom severity ≥2, were compared to those with lesser symptom severity or symptom resolution.

Results

There were 9 (25.7%; 95%CI: 12.5-43.3) patients who reported persistent symptoms. Day of injury plasma miR-223-3p levels were significantly higher in individuals with ongoing symptoms compared to those without, however, no such differences were observed for miRs 142-3p, 423-3p, 32-5p, 144-3p, and let-7f-5p.

Conclusion

Acute plasma miR-223-3p levels appear to detect patients who later have persistent symptoms after mTBI. The results demonstrate the potential utility for such biomarkers to assist in decisions towards early referral for therapy after mTBI.

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MicroRNA Biomarkers on Day of Injury Among Patients with Post Concussive Symptoms at 28-Days: A Prospective Cohort Study

MicroRNA 13, 233 (2024); https://doi.org/10.2174/0122115366297817240613065052

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Article Type: Research Article

Keyword(s): biomarkers; brain concussion; Brain injuries; MicroRNAs; post-concussion syndrome; traumatic

MicroRNA Biomarkers on Day of Injury Among Patients with Post Concussive Symptoms at 28-Days: A Prospective Cohort Study

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