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Volume 13, Issue 3
  • ISSN: 2211-5366
  • E-ISSN: 2211-5374
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Abstract

Background

Hydrolethalus Syndrome 1 (HYDS1) is a rare disorder that occurs commonly in Finnish infants but originates from the mother. This autosomal recessive syndrome is associated with the which is usually expressed in the centriole. The is an inheritable arthritis disease phenotype that includes rheumatoid arthritis. Several studies have investigated males with mutation carriers also related to arthritis diseases, including those under rheumatoid arthritis conditions, which revealed the possibility of conferring the gene mutation to the next generation of offspring. Nonetheless, there are some complications of mutation with target miRNAs that can be affected by exercise.

Objective

The objective of this study was to evaluate the different exercises that can be utilized to suppress the mutation targeted by Novel-rno-miRNAs-1135 as a biomarker and assess the effectiveness of exercise in mitigating the mutation.

Methods

Four exercise interventional groups were divided into exercise and non-exercise groups. One hundred microliter pristane-induced arthritis (PIA) was injected at the dorsal region of the tails of rodents and introduced to the two PIA interventional groups. On day forty-five, all animals were euthanized, and total RNA was extracted from the blood samples of rodents, while polymerase chain reaction (PCR) was amplified by using 5-7 primers. Computerization was used for miRNA regulation and analysis of target gene candidates.

Results

The novel-rno-miRNA-1135 was downregulated to in exercise groups. The exercise was found to have no significant impact in terms of change in novel-rno-miRNA-1135 regulation of expression.

Conclusion

Exercise has no impact on novel-rno-miRNA-1135 targeted for in autosomal recessive disease.

© 2024 Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-11-01
2024-11-22

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/content/journals/mirna/10.2174/0122115366294831240606115216
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Exercise Alters FBF1-Regulated Novel-miRNA-1135 Associated with Hydrolethalus Syndrome 1 in Rheumatoid Arthritis: A Preliminary Study
MicroRNA 13, 225 (2024); https://doi.org/10.2174/0122115366294831240606115216
/content/journals/mirna/10.2174/0122115366294831240606115216
/content/journals/mirna/10.2174/0122115366294831240606115216
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  • Article Type:     Research Article
Keyword(s): autosomal; exercise; hydrolethalus syndrome; miRNA; Novel; rheumatoid arthritis
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