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2000
Volume 18, Issue 2
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Background: Thiobezimidazoles reveal various pharmacological activities due to similarities with many natural and synthetic molecules; they can easily interact with biomolecules of living systems. Objective: A series of substituted 2-thiobezimidazoles have been synthesized. Twelve final compounds were screened for anti-cancer activities against sixty different cell lines. Methods: The spectral data of the synthesized compounds were characterized. A docking study for active anticancer compounds and CDK2/CyclinA2 Kinase assay against standard reference; Imatinib, were performed. Results: Two compounds (3c&3l) from the examined series revealed effective antitumor activity against two-cancer cell lines (Colon Cancer (HCT-116) and Renal Cancer (TK-10). The docking study of synthesized molecules discovered a requisite binding pose in the CDK-ATP binding pocket .3c &3l were promoted in the CDK2/CyclinA2 Kinase assay against standard reference Imatinib. Conclusion: Against all tested compounds; two compounds 3c &3l were found active against two types of cell-lines.

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/content/journals/mc/10.2174/1573406417666210304100830
2022-02-01
2025-06-15
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  • Article Type:
    Research Article
Keyword(s): 2-thiobenzimidazoles; Anti-cancer; CDK2 assay; docking; spectroscopic analysis; Synthesis
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