Skip to content
2000
Volume 12, Issue 4
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Hypoxia inducible factor-1 (HIF-1) is a key mediator during cancer cells to adapt tumor hypoxic condition. In this study, a series of adamantane-based compounds were synthesized and evaluated as potential inhibitors of HIF-1α. Examination of their structure-activity relationship (SAR) identified the adamantane-containing indole derivative 20a as a potent inhibitor of HIF-1α in Hep3B cell lines under tumor hypoxia (IC50 = 0.02 μM). The study herein may provide valuable information for the development of novel therapeutics against cancer and tumor angiogenesis.

Loading

Article metrics loading...

/content/journals/mc/10.2174/1573406412666151109113007
2016-06-01
2025-06-09
Loading full text...

Full text loading...

/content/journals/mc/10.2174/1573406412666151109113007
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test